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MA29485B1 - Motilides - Google Patents

Motilides

Info

Publication number
MA29485B1
MA29485B1 MA30419A MA30419A MA29485B1 MA 29485 B1 MA29485 B1 MA 29485B1 MA 30419 A MA30419 A MA 30419A MA 30419 A MA30419 A MA 30419A MA 29485 B1 MA29485 B1 MA 29485B1
Authority
MA
Morocco
Prior art keywords
motilides
procintic
agents
employed
formula
Prior art date
Application number
MA30419A
Other languages
English (en)
Inventor
Yaoquan Liu
Christopher Carreras
David C Myles
Yong Li
Simon James Shaw
Hong Fu
Yue Chen
Hao Zheng
Yandong Li
Mark A Burlingame
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MA29485B1 publication Critical patent/MA29485B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Otolaryngology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

COMPOSÉS DE STRUCTURE RÉPONDANT À LA FORMULE (I) OÙ RA, RB, RC, RD, RE, ET RF SONT TELS QUE DÉFINIS DANS LA PRÉSENTE POUVANT ÊTRE EMPLOYÉS EN TANT QU'AGENTS PROCINÉTIQUES.
MA30419A 2005-05-24 2007-11-23 Motilides MA29485B1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US68461205P 2005-05-24 2005-05-24
US71540605P 2005-09-08 2005-09-08
US74889805P 2005-12-08 2005-12-08
US11/416,519 US7582611B2 (en) 2005-05-24 2006-05-02 Motilide compounds

Publications (1)

Publication Number Publication Date
MA29485B1 true MA29485B1 (fr) 2008-05-02

Family

ID=37452327

Family Applications (1)

Application Number Title Priority Date Filing Date
MA30419A MA29485B1 (fr) 2005-05-24 2007-11-23 Motilides

Country Status (19)

Country Link
US (1) US7582611B2 (fr)
EP (1) EP1888082B1 (fr)
JP (1) JP4197359B2 (fr)
KR (1) KR100956465B1 (fr)
AP (1) AP2337A (fr)
AU (1) AU2006249555B2 (fr)
BR (1) BRPI0611374A2 (fr)
CA (1) CA2609494C (fr)
CU (1) CU23750B7 (fr)
EA (1) EA014711B1 (fr)
ES (1) ES2392860T3 (fr)
GE (1) GEP20094854B (fr)
IL (1) IL186752A (fr)
MA (1) MA29485B1 (fr)
MX (1) MX2007014255A (fr)
NO (1) NO20076464L (fr)
NZ (1) NZ562891A (fr)
TN (1) TNSN07436A1 (fr)
WO (1) WO2006127252A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070135362A1 (en) * 2005-12-08 2007-06-14 Yaoquan Liu Method for demethylating the 3'-dimethylamino group of erythromycin compounds
US9133235B2 (en) 2006-09-11 2015-09-15 Ocera Therapeutics, Inc. Macrocyclic antagonists of the motilin receptor for treatment of gastrointestinal dysmotility disorders
BRPI0719565A2 (pt) * 2006-12-05 2013-12-10 Pfizer Polimorfos de motilídeo
US20080287371A1 (en) * 2007-05-17 2008-11-20 Tranzyme Pharma Inc. Macrocyclic antagonists of the motilin receptor for modulation of the migrating motor complex
US8349852B2 (en) 2009-01-13 2013-01-08 Novartis Ag Quinazolinone derivatives useful as vanilloid antagonists
JP5663743B2 (ja) 2009-02-27 2015-02-04 ラクオリア創薬株式会社 モチリン受容体作動活性を有するオキシインドール誘導体
WO2011092293A2 (fr) 2010-02-01 2011-08-04 Novartis Ag Dérivés de cyclohexylamide utilisés en tant qu'antagonistes du récepteur du crf
US20120295942A1 (en) 2010-02-01 2012-11-22 Nicholas James Devereux Pyrazolo[5,1b]oxazole Derivatives as CRF-1 Receptor Antagonists
CN102753527B (zh) 2010-02-02 2014-12-24 诺华股份有限公司 用作crf受体拮抗剂的环己基酰胺衍生物

Family Cites Families (38)

* Cited by examiner, † Cited by third party
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US3983103A (en) * 1973-01-19 1976-09-28 Pliva Pharmaceutical And Chemical Works N-(Benzenesulfonyl)-erythromycylamine derivatives
YU35369B (en) 1973-01-19 1980-12-31 Pliva Zagreb Process for preparing n-(benzenesulfonyl)-erythromycilamine derivatives
US3855200A (en) * 1973-04-23 1974-12-17 Polska Akademia Nauk Instytut Process for preparing 8-hydroxyerthromycin a and intermediates therefor
YU35363B (en) * 1974-01-14 1980-12-31 Pliva Zagreb Process for obtaining n-(benzene-sulfonyl)-5-0desosaminyl-erythromycilamine derivatives
US4331803A (en) 1980-06-04 1982-05-25 Taisho Pharmaceutical Co., Ltd. Novel erythromycin compounds
IT1196041B (it) * 1984-03-08 1988-11-10 Pierrel Spa Emichetali di (8s)-8-fluoroeritromicine,il procedimento per la loro preparazione e le formulazioni adatte alla somministrazione orale che contengono i prodotti
JPS60218321A (ja) 1984-04-13 1985-11-01 Satoshi Omura 消化管収縮運動促進剤
US5175150A (en) * 1985-08-31 1992-12-29 Kitasato, Kenkyusho Erythromycin derivative
US5008249A (en) * 1985-08-31 1991-04-16 Kitasato Kenkyusho Therapeutic method of stimulating digestive tract contractile motion in mammals
IL114589A (en) * 1990-11-21 1999-12-22 Roussel Uclaf Intermediates for the preparation of erythromycin derivatives
US5523401A (en) * 1991-04-09 1996-06-04 Abbott Laboratories Macrocyclic lactam prokinetic agents
DE69211845T2 (de) * 1991-04-09 1997-01-23 Abbott Lab Macrozyklische laktam-prokinetika
DE4200145A1 (de) * 1992-01-07 1993-07-08 Kali Chemie Pharma Gmbh 7,10-epoxy-oxacyclododecan-derivate, verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
MX9300278A (es) * 1992-01-21 1993-12-31 Abbott Lab Compuestos de arilalcoxifenoxi-imidazolina.
DE69302938T2 (de) * 1992-03-19 1996-10-17 Kitasato Inst Erythromycinderivate, Herstellung und Verwendung davon
MY113693A (en) * 1992-05-26 2002-05-31 Chugai Pharmaceutical Co Ltd Erythromycin derivatives having an enterokinesis stimulating action
ZA966601B (en) * 1995-08-03 1997-02-19 Chugai Pharmaceutical Co Ltd Process for producing erythromycin derivatives.
AU2340797A (en) 1996-05-07 1997-11-26 Abbott Laboratories 6-o-substituted erythromycins and method for making them
US5712253A (en) * 1996-06-18 1998-01-27 Abbott Laboratories Macrocyclic 13-membered ring derivatives of erythromycins A and B
GEP20012348B (en) * 1996-07-05 2001-01-25 Pfizer Erythromycins and Process for Their Preparation
HRP960497B1 (en) * 1996-10-28 2003-08-31 Pliva Pharm & Chem Works 9-n-ethenyl derivatives of 9(s)-erythromycylamine
US5922849A (en) * 1996-11-22 1999-07-13 Abbott Laboratories Process for preparation of N-demethyl-4"-deoxy-erthromycins A and B
WO1999021868A1 (fr) * 1997-10-29 1999-05-06 Taisho Pharmaceutical Co., Ltd. Derives d'erythromycine a
US6084079A (en) * 1998-05-15 2000-07-04 Keyes; Robert F. Process for preparing N-demethyl-N-alkyl erythromycin derivatives
KR100317907B1 (ko) * 1998-11-24 2001-12-24 김 완 주 신규한 중간체, 이를 이용한 마크로라이드계 항생제의제조방법
IT1306205B1 (it) * 1999-01-15 2001-05-30 Zambon Spa Macrolidi ad attivita' antiinfiammatoria.
EP1255763A2 (fr) * 2000-02-18 2002-11-13 Kosan Biosciences, Inc. Composes motilides
EP1314737A4 (fr) * 2000-09-01 2008-03-26 Chugai Pharmaceutical Co Ltd Procede permettant la production d'un derive d'erythromycine
US20020094962A1 (en) * 2000-12-01 2002-07-18 Gary Ashley Motilide compounds
CA2437576A1 (fr) * 2001-02-15 2002-08-22 Kosan Biosciences, Inc. Procede pour evaluer l'efficacite therapeutique
JP2002241391A (ja) 2001-02-15 2002-08-28 Taisho Pharmaceut Co Ltd エリスロマイシンａ誘導体
US6946482B2 (en) 2002-08-29 2005-09-20 Kosan Biosciences, Inc. Motilide compounds
US20050113319A1 (en) * 2003-08-26 2005-05-26 Christopher Carreras 11-Deoxy-6,9-ether erythromycin compounds
US7407941B2 (en) * 2003-08-26 2008-08-05 Pfizer, Inc. N-desmethyl-N-substituted-11-deoxyerythromycin compounds
US20070149463A1 (en) * 2003-10-30 2007-06-28 Oyelere Adegboyega K Bifunctional macrolide heterocyclic compounds and methods of making and using the same
US7211568B2 (en) * 2003-12-18 2007-05-01 Kosan Biosciences Incorporated 9-Desoxoerythromycin compounds as prokinetic agents
US20060075011A1 (en) * 2004-09-23 2006-04-06 Fujitsu Limited System and method for optimizing polynomial expressions in a processing environment
TW200633714A (en) 2004-12-28 2006-10-01 Chugai Pharmaceutical Co Ltd Drugs for the treatment and/or prophylaxis of gastroparesis symptom

Also Published As

Publication number Publication date
US20060270616A1 (en) 2006-11-30
ES2392860T3 (es) 2012-12-14
AU2006249555A8 (en) 2006-11-30
MX2007014255A (es) 2008-01-22
CU20070261A7 (es) 2009-07-16
EP1888082A4 (fr) 2008-12-17
CA2609494C (fr) 2010-12-21
CU23750B7 (es) 2012-01-31
HK1117739A1 (en) 2009-01-23
JP2008542268A (ja) 2008-11-27
GEP20094854B (en) 2009-12-10
AP2007004220A0 (en) 2007-10-31
JP4197359B2 (ja) 2008-12-17
EP1888082B1 (fr) 2012-09-12
EA014711B1 (ru) 2011-02-28
AU2006249555B2 (en) 2009-07-16
AU2006249555A1 (en) 2006-11-30
NZ562891A (en) 2011-01-28
EP1888082A1 (fr) 2008-02-20
BRPI0611374A2 (pt) 2010-08-31
IL186752A0 (en) 2008-02-09
TNSN07436A1 (fr) 2009-03-17
IL186752A (en) 2011-10-31
WO2006127252A1 (fr) 2006-11-30
NO20076464L (no) 2008-02-22
KR20080013922A (ko) 2008-02-13
CA2609494A1 (fr) 2006-11-30
KR100956465B1 (ko) 2010-05-07
US7582611B2 (en) 2009-09-01
EA200702290A1 (ru) 2008-04-28
AP2337A (en) 2011-12-14

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