MA27375A1 - Promedicaments 2' et3' de nucleoside permettant de traiter des infections par les flaviviridae - Google Patents
Promedicaments 2' et3' de nucleoside permettant de traiter des infections par les flaviviridaeInfo
- Publication number
- MA27375A1 MA27375A1 MA28072A MA28072A MA27375A1 MA 27375 A1 MA27375 A1 MA 27375A1 MA 28072 A MA28072 A MA 28072A MA 28072 A MA28072 A MA 28072A MA 27375 A1 MA27375 A1 MA 27375A1
- Authority
- MA
- Morocco
- Prior art keywords
- nucleoside
- medicaments
- flaviviridae infections
- treating flaviviridae
- treating
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39235002P | 2002-06-28 | 2002-06-28 | |
| US39235102P | 2002-06-28 | 2002-06-28 | |
| US46619403P | 2003-04-28 | 2003-04-28 | |
| US47094903P | 2003-05-14 | 2003-05-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA27375A1 true MA27375A1 (fr) | 2005-06-01 |
Family
ID=30003988
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA28072A MA27375A1 (fr) | 2002-06-28 | 2005-01-26 | Promedicaments 2' et3' de nucleoside permettant de traiter des infections par les flaviviridae |
Country Status (28)
| Country | Link |
|---|---|
| EP (3) | EP1523489B1 (fr) |
| JP (7) | JP2005533817A (fr) |
| KR (1) | KR20050048544A (fr) |
| CN (6) | CN103319554A (fr) |
| AP (1) | AP2005003212A0 (fr) |
| AR (2) | AR043101A1 (fr) |
| AU (1) | AU2003247084B9 (fr) |
| BR (2) | BR0312286A (fr) |
| CA (1) | CA2490191C (fr) |
| CY (2) | CY1115417T1 (fr) |
| DE (1) | DE14169110T1 (fr) |
| DK (1) | DK1523489T3 (fr) |
| ES (1) | ES2469569T3 (fr) |
| FR (1) | FR14C0059I1 (fr) |
| HK (2) | HK1204624A1 (fr) |
| IL (1) | IL165893A0 (fr) |
| MA (1) | MA27375A1 (fr) |
| MX (1) | MXPA04012709A (fr) |
| MY (1) | MY140819A (fr) |
| NO (3) | NO330755B1 (fr) |
| PE (3) | PE20040634A1 (fr) |
| PL (1) | PL374831A1 (fr) |
| PT (1) | PT1523489E (fr) |
| RS (1) | RS114004A (fr) |
| RU (1) | RU2483075C2 (fr) |
| TW (3) | TW200500374A (fr) |
| UY (3) | UY27875A1 (fr) |
| WO (1) | WO2004002999A2 (fr) |
Families Citing this family (159)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| NZ547204A (en) | 2000-05-26 | 2008-01-31 | Idenix Cayman Ltd | Methods and compositions for treating flaviviruses and pestiviruses |
| US6875751B2 (en) | 2000-06-15 | 2005-04-05 | Idenix Pharmaceuticals, Inc. | 3′-prodrugs of 2′-deoxy-β-L-nucleosides |
| AU2003248748A1 (en) | 2002-06-28 | 2004-01-19 | Idenix (Cayman) Limited | 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
| NZ537662A (en) | 2002-06-28 | 2007-10-26 | Idenix Cayman Ltd | 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
| MY140819A (en) | 2002-06-28 | 2010-01-29 | Idenix Caymans Ltd | Modified 2' and 3'-nucleoside prodrugs for treating flaviviridae |
| US7323449B2 (en) | 2002-07-24 | 2008-01-29 | Merck & Co., Inc. | Thionucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase |
| DE10238722A1 (de) | 2002-08-23 | 2004-03-11 | Bayer Ag | Selektive Phosphodiesterase 9A-Inhibitoren als Arzneimittel zur Verbesserung kognitiver Prozesse |
| WO2004041837A1 (fr) | 2002-10-31 | 2004-05-21 | Metabasis Therapeutics, Inc. | Nouveaux promedicaments de cytarabine monophosphate |
| US7824851B2 (en) | 2002-11-15 | 2010-11-02 | Idenix Pharmaceuticals, Inc. | 2′-branched nucleosides and Flaviviridae mutation |
| KR20050109918A (ko) | 2002-12-12 | 2005-11-22 | 이데닉스 (케이만) 리미티드 | 2'-분지형 뉴클레오시드의 제조 방법 |
| CA2734052A1 (fr) | 2003-05-30 | 2005-01-13 | Pharmasset, Inc. | Analogues de nucleosides fluores modifies |
| GB0317009D0 (en) | 2003-07-21 | 2003-08-27 | Univ Cardiff | Chemical compounds |
| CN1852915A (zh) | 2003-07-25 | 2006-10-25 | 艾登尼科斯(开曼)有限公司 | 治疗包括丙型肝炎的黄病毒科病毒所致疾病的嘌呤核苷类似物 |
| US20050182252A1 (en) | 2004-02-13 | 2005-08-18 | Reddy K. R. | Novel 2'-C-methyl nucleoside derivatives |
| CN103319464A (zh) | 2004-02-20 | 2013-09-25 | 贝林格尔.英格海姆国际有限公司 | 病毒聚合酶抑制剂 |
| EP1758453B1 (fr) | 2004-06-15 | 2014-07-16 | Merck Sharp & Dohme Corp. | Analogues nucleosidiques de c-purine, servant d'inhibiteurs d'arn-polymerase virale arn-dependante |
| CN101023094B (zh) | 2004-07-21 | 2011-05-18 | 法莫赛特股份有限公司 | 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备 |
| BRPI0515279A (pt) | 2004-09-14 | 2008-07-15 | Pharmasset Inc | preparação de ribofuranosil pirimidinas e purinas 2'fluoro-2'-alquil- substituìdas ou outras opcionalmente substituìdas e seus derivados |
| BRPI0515896A (pt) * | 2004-09-24 | 2008-08-12 | Idenix Cayman Ltd E Ct Nat De | composto ou um sal ou éster farmaceuticamente aceitável do mesmo, método para o tratamento ou profilaxia de um hospedeiro infectado com uma infecção por flavivìrus, pestivìrus ou hepacivìrus, e, composição farmacêutica para o tratamento de um hospedeiro infectado com uma infecção por flavivìrus, pestivìrus ou hepacivìrus |
| JP4705164B2 (ja) | 2005-05-02 | 2011-06-22 | メルク・シャープ・エンド・ドーム・コーポレイション | Hcvns3プロテアーゼ阻害剤 |
| TWI387603B (zh) | 2005-07-20 | 2013-03-01 | Merck Sharp & Dohme | Hcv ns3蛋白酶抑制劑 |
| JP4705984B2 (ja) | 2005-08-01 | 2011-06-22 | メルク・シャープ・エンド・ドーム・コーポレイション | Hcvns3プロテアーゼ阻害剤としての大環状ペプチド |
| CN101336247B (zh) | 2005-12-09 | 2013-01-23 | 豪夫迈·罗氏有限公司 | 抗病毒核苷 |
| US8895531B2 (en) | 2006-03-23 | 2014-11-25 | Rfs Pharma Llc | 2′-fluoronucleoside phosphonates as antiviral agents |
| CN101460488A (zh) | 2006-04-04 | 2009-06-17 | 弗·哈夫曼-拉罗切有限公司 | 用于hcv治疗的3’,5’-二-o-酰化核苷 |
| GB0609178D0 (en) | 2006-05-09 | 2006-06-21 | Univ Cardiff | Novel compounds |
| GB0609492D0 (en) | 2006-05-15 | 2006-06-21 | Angeletti P Ist Richerche Bio | Therapeutic agents |
| US8058260B2 (en) | 2006-05-22 | 2011-11-15 | Xenoport, Inc. | 2′-C-methyl-ribofuranosyl cytidine prodrugs, pharmaceutical compositions and uses thereof |
| GB0612423D0 (en) | 2006-06-23 | 2006-08-02 | Angeletti P Ist Richerche Bio | Therapeutic agents |
| CN101600725B (zh) | 2006-10-10 | 2014-11-26 | 吉利德制药有限责任公司 | 制备呋喃核糖基嘧啶核苷 |
| SI2084175T1 (sl) | 2006-10-10 | 2011-05-31 | Medivir Ab | Hcv nukleozidni inhibitor |
| CA2667266C (fr) | 2006-10-24 | 2015-11-24 | Merck & Co., Inc. | Inhibiteurs de la protease ns3 du hcv |
| EP2076278B1 (fr) | 2006-10-24 | 2015-05-06 | Merck Sharp & Dohme Corp. | Inhibiteurs macrocycliques de la protéase HCV NS3 |
| EP2079479B1 (fr) | 2006-10-24 | 2014-11-26 | Merck Sharp & Dohme Corp. | Inhibiteurs de la protéase ns3 du vhc |
| WO2008057208A2 (fr) | 2006-10-27 | 2008-05-15 | Merck & Co., Inc. | Inhibiteurs de protéase ns3 du vhc |
| KR101615500B1 (ko) | 2006-10-27 | 2016-04-27 | 머크 샤프 앤드 돔 코포레이션 | Hcv ns3 프로테아제 억제제 |
| CN101528717B (zh) | 2006-11-09 | 2013-04-24 | 弗·哈夫曼-拉罗切有限公司 | 噻唑和*唑-取代的芳基酰胺类化合物 |
| GB0625349D0 (en) | 2006-12-20 | 2007-01-31 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
| GB0625345D0 (en) | 2006-12-20 | 2007-01-31 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
| WO2008075103A1 (fr) | 2006-12-20 | 2008-06-26 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa | Indoles antiviraux |
| US20080261913A1 (en) | 2006-12-28 | 2008-10-23 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of liver disorders |
| JP2010515680A (ja) | 2007-01-05 | 2010-05-13 | メルク・シャープ・エンド・ドーム・コーポレイション | Rna依存性rnaウイルス感染症の治療用としてのヌクレオシドアリールホスホロアミデート |
| US7964580B2 (en) | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
| EP2178886A1 (fr) | 2007-07-17 | 2010-04-28 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Dérivés macrocycliques d'indole pour le traitement des infections d'hépatite c |
| US8927569B2 (en) | 2007-07-19 | 2015-01-06 | Merck Sharp & Dohme Corp. | Macrocyclic compounds as antiviral agents |
| WO2009068617A1 (fr) | 2007-11-30 | 2009-06-04 | Boehringer Ingelheim International Gmbh | Dérivés de 1,5-dihydro-pyrazolo(3,4-d)pyrimidin-4-one et leur utilisation en tant que modulateurs de pde9a pour le traitement de troubles du snc |
| MX2010006230A (es) | 2007-12-17 | 2010-06-23 | Hoffmann La Roche | Derivados de arilamida substituidos con triazol y su uso como antagonistas de receptor purinergico p2x3 y/o p2x2/3. |
| HRP20130614T1 (en) | 2007-12-17 | 2013-08-31 | F. Hoffmann - La Roche Ag | Novel pyrazole-substituted arylamides |
| KR101290385B1 (ko) | 2007-12-17 | 2013-07-29 | 에프. 호프만-라 로슈 아게 | 테트라졸-치환된 아릴아미드 유도체 및 p2x3 및/또는 p2x2/3 퓨린성 수용체 길항제로서의 이들의 용도 |
| CA2708791C (fr) | 2007-12-17 | 2016-06-21 | F. Hoffmann-La Roche Ag | Arylamides a imidazole substitue et leurs utilisations comme antagonistes du recepteur p2x |
| US8227431B2 (en) | 2008-03-17 | 2012-07-24 | Hetero Drugs Limited | Nucleoside derivatives |
| TW200946541A (en) | 2008-03-27 | 2009-11-16 | Idenix Pharmaceuticals Inc | Solid forms of an anti-HIV phosphoindole compound |
| UA105362C2 (en) | 2008-04-02 | 2014-05-12 | Бьорингер Ингельхайм Интернациональ Гмбх | 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators |
| CA2722308C (fr) | 2008-04-15 | 2024-02-27 | Rfs Pharma, Llc. | Derives nucleosidiques destines au traitement d'infections par un virus de la famille des caliciviridae, y compris d'infections par le norovirus |
| WO2009134624A1 (fr) | 2008-04-28 | 2009-11-05 | Merck & Co., Inc. | Inhibiteurs de la protéase hcv ns3 |
| UY31950A (es) * | 2008-07-01 | 2010-01-29 | Medivir Ab | Inhibidores de ciclopropil-polimerasa |
| ES2458358T3 (es) | 2008-07-02 | 2014-05-05 | Idenix Pharmaceuticals, Inc. | Compuestos y composiciones farmacéuticas para el tratamiento de infecciones víricas |
| UA100436C2 (en) | 2008-07-22 | 2012-12-25 | Mepk Шарп Энд Доме Корп. | Macrocyclic quinoxaline compounds as hcv ns3 protease inhibitors |
| US8629275B2 (en) | 2008-09-08 | 2014-01-14 | Merck Sharp & Dohme Corp. | AHCY hydrolase inhibitors for treatment of hyper homocysteinemia |
| MX2011002340A (es) | 2008-09-08 | 2011-04-04 | Boehringer Ingelheim Int | Pirazolopirimidinas y su uso para el tratamiento de trastornos del snc. |
| PA8852101A1 (es) | 2008-12-08 | 2010-07-27 | Medivir Ab | Nucleótidos uracil ciclopropílicos |
| EP2376514A2 (fr) | 2008-12-23 | 2011-10-19 | Pharmasset, Inc. | Analogues de nucléoside |
| US8716262B2 (en) | 2008-12-23 | 2014-05-06 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
| WO2010075554A1 (fr) | 2008-12-23 | 2010-07-01 | Pharmasset, Inc. | Synthèse de nucléosides de type purine |
| WO2010082050A1 (fr) | 2009-01-16 | 2010-07-22 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Composés benzoxazocines substitués 7-aminoalkyle macrocycycliques destinés au traitement des infections par hépatite c |
| GB0900914D0 (en) | 2009-01-20 | 2009-03-04 | Angeletti P Ist Richerche Bio | Antiviral agents |
| EP2403860B1 (fr) | 2009-03-04 | 2015-11-04 | IDENIX Pharmaceuticals, Inc. | Composes phosphothiophene and phosphothiazole comme agent d'inhibiteur polymerase hcv |
| BRPI1011533A2 (pt) | 2009-03-31 | 2016-03-29 | Boehringer Ingelheim Int | derivados de 1-heterocicil-1 5- diidro-pirazolo [3,4--d] pirimidin-4-ona e seu uso como moduladores de pde9a. |
| TWI583692B (zh) | 2009-05-20 | 2017-05-21 | 基利法瑪席特有限責任公司 | 核苷磷醯胺 |
| US8618076B2 (en) | 2009-05-20 | 2013-12-31 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
| CN102574778B (zh) | 2009-06-22 | 2015-01-07 | 弗·哈夫曼-拉罗切有限公司 | 新的联苯基和苯基-吡啶酰胺类化合物 |
| ES2457543T3 (es) | 2009-06-22 | 2014-04-28 | F. Hoffmann-La Roche Ag | Nuevas arilamidas de indazol como antagonistas de P2X3 y/o P2X2/3 |
| SG176640A1 (en) | 2009-06-22 | 2012-01-30 | Hoffmann La Roche | Novel oxazolone and pyrrolidinone-substituted arylamides |
| WO2011014487A1 (fr) | 2009-07-30 | 2011-02-03 | Merck Sharp & Dohme Corp. | Inhibiteurs de protéase ns3 du virus de l'hépatite c |
| CA2769652A1 (fr) | 2009-08-05 | 2011-02-10 | Idenix Pharmaceuticals, Inc. | Inhibiteurs macrocycliques de la serine protease macrocyclique utiles contre les infections virales, en particulier le virus de l?hepatite c |
| KR20120104239A (ko) | 2009-11-14 | 2012-09-20 | 에프. 호프만-라 로슈 아게 | Hcv 치료에 대한 신속한 반응을 예측하기 위한 바이오마커 |
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- 2003-06-27 EP EP14169110.5A patent/EP2799442A1/fr not_active Withdrawn
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