MA27316A1 - Derives d'indoline-phenylsulfonamide - Google Patents
Derives d'indoline-phenylsulfonamideInfo
- Publication number
- MA27316A1 MA27316A1 MA28032A MA28032A MA27316A1 MA 27316 A1 MA27316 A1 MA 27316A1 MA 28032 A MA28032 A MA 28032A MA 28032 A MA28032 A MA 28032A MA 27316 A1 MA27316 A1 MA 27316A1
- Authority
- MA
- Morocco
- Prior art keywords
- derivatives
- indoline
- indolinephenylsulfonamide
- phenylsulfonamide derivatives
- phenylsulfonamide
- Prior art date
Links
- ZFJPEIIOZIZJAB-UHFFFAOYSA-N benzenesulfonamide;2,3-dihydro-1h-indole Chemical class C1=CC=C2NCCC2=C1.NS(=O)(=O)C1=CC=CC=C1 ZFJPEIIOZIZJAB-UHFFFAOYSA-N 0.000 title 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 208000032928 Dyslipidaemia Diseases 0.000 abstract 1
- 208000017170 Lipid metabolism disease Diseases 0.000 abstract 1
- 102100038824 Peroxisome proliferator-activated receptor delta Human genes 0.000 abstract 1
- 230000003213 activating effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000029078 coronary artery disease Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 108091008765 peroxisome proliferator-activated receptors β/δ Proteins 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/96—Spiro-condensed ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
DERIVES D'INDOLINEPHENYLSULFONAMIDE La présente demande concerne de nouveaux dérivés d'indolinephénylsulfonamide substitués, des procédés pour leur préparation, et leur utilisation dans des médicaments, en particulier en tant que composés puissants d'activation de PPAR-delta pour la prophylaxie et/ou le traitement de troubles cardiovasculaires, en particulier de dyslipidémies et de maladies coronariennes.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10229777A DE10229777A1 (de) | 2002-07-03 | 2002-07-03 | Indolin-Phenylsulfonamid-Derivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA27316A1 true MA27316A1 (fr) | 2005-05-02 |
Family
ID=29796112
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA28032A MA27316A1 (fr) | 2002-07-03 | 2005-01-03 | Derives d'indoline-phenylsulfonamide |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US20060100230A1 (fr) |
| EP (1) | EP1519919A1 (fr) |
| JP (1) | JP2005535649A (fr) |
| CN (1) | CN1678581A (fr) |
| AR (1) | AR040352A1 (fr) |
| AU (1) | AU2003246638A1 (fr) |
| BR (1) | BR0312549A (fr) |
| CA (1) | CA2491477A1 (fr) |
| DE (1) | DE10229777A1 (fr) |
| EC (1) | ECSP055524A (fr) |
| GT (1) | GT200300135A (fr) |
| HN (1) | HN2003000196A (fr) |
| HR (1) | HRP20050108A2 (fr) |
| IL (1) | IL165924A0 (fr) |
| MA (1) | MA27316A1 (fr) |
| MX (1) | MXPA05000133A (fr) |
| MY (1) | MY134641A (fr) |
| NO (1) | NO20050579L (fr) |
| NZ (1) | NZ537486A (fr) |
| PE (1) | PE20040645A1 (fr) |
| RU (1) | RU2328485C2 (fr) |
| TW (1) | TW200418794A (fr) |
| UA (1) | UA79003C2 (fr) |
| UY (1) | UY27878A1 (fr) |
| WO (1) | WO2004005253A1 (fr) |
| ZA (1) | ZA200500013B (fr) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10335450A1 (de) * | 2003-08-02 | 2005-02-17 | Bayer Ag | Indolin-Sulfanilsäureamide |
| DE10337839A1 (de) * | 2003-08-18 | 2005-03-17 | Bayer Healthcare Ag | Indolin-Derivate |
| JP2007504271A (ja) * | 2003-09-05 | 2007-03-01 | ニューロジェン・コーポレーション | Crf1受容体リガンドである、ヘテロアリール縮合ピリジン類、ピラジン類及びピリミジン類 |
| AR048523A1 (es) * | 2004-04-07 | 2006-05-03 | Kalypsys Inc | Compuestos con estructura de aril sulfonamida y sulfonilo como moduladores de ppar y metodos para tratar trastornos metabolicos |
| EP1745003B1 (fr) | 2004-05-05 | 2010-10-27 | High Point Pharmaceuticals, LLC | Nouveaux composes, leur preparation et leur utilisation |
| WO2005105736A1 (fr) | 2004-05-05 | 2005-11-10 | Novo Nordisk A/S | Nouveaux composes, leur preparation et leur utilisation |
| FR2869904B1 (fr) | 2004-05-07 | 2006-07-28 | Fournier S A Sa Lab | Modulateurs des recepteurs lxr |
| FR2873694B1 (fr) * | 2004-07-27 | 2006-12-08 | Merck Sante Soc Par Actions Si | Nouveaux aza-indoles inhibiteurs de la mtp et apob |
| DK1805158T3 (en) * | 2004-10-29 | 2018-08-06 | Kalypsys Inc | SULFONYL-SUBSTITUTED BICYCLIC COMPOUNDS AS MODULATORS OF PPAR |
| CN101421258B (zh) * | 2004-10-29 | 2013-08-21 | 凯利普西斯公司 | 作为ppar调节剂的磺酰基取代的双环化合物 |
| RU2007131501A (ru) * | 2005-01-18 | 2009-02-27 | Новартис АГ (CH) | Способы применения двойных агонистов ppar и устройств для доставки лекарственных средств, содержащих такие соединения |
| DE102005020230A1 (de) * | 2005-04-30 | 2006-11-09 | Bayer Healthcare Ag | Verwendung von Indolin-Phenylsulfonamid-Derivaten |
| DE102005020229A1 (de) * | 2005-04-30 | 2006-11-09 | Bayer Healthcare Ag | Verwendung von Indolin-Phenylsulfonamid-Derivaten |
| FR2886293B1 (fr) * | 2005-05-30 | 2007-08-24 | Fournier S A Sa Lab | Nouveaux composes de l'indoline |
| ATE529404T1 (de) | 2005-06-30 | 2011-11-15 | High Point Pharmaceuticals Llc | Phenoxyessigsäuren als ppar-delta-aktivatoren |
| FR2890072A1 (fr) * | 2005-09-01 | 2007-03-02 | Fournier S A Sa Lab | Nouveaux composesde pyrrolopyridine |
| CN103224477A (zh) | 2005-12-22 | 2013-07-31 | 高点制药有限责任公司 | 作为PPAR-δ活化剂的苯氧基乙酸 |
| EP1999098A2 (fr) | 2006-03-09 | 2008-12-10 | High Point Pharmaceuticals, LLC | Nouveaux composés, leur préparation et utilisation |
| TWI315304B (en) | 2006-08-31 | 2009-10-01 | Univ Taipei Medical | Indoline-sulfonamides compounds |
| EP1932843A1 (fr) * | 2006-12-14 | 2008-06-18 | sanofi-aventis | Dérivés de sulfonyl-phenyl-2H(1,2,4) oxadiazole-5-one, procédés de préparation de ceux-ci et leur usage sous forme de médicaments |
| US20080176861A1 (en) | 2007-01-23 | 2008-07-24 | Kalypsys, Inc. | Sulfonyl-substituted bicyclic compounds as ppar modulators for the treatment of non-alcoholic steatohepatitis |
| TW200848021A (en) | 2007-03-06 | 2008-12-16 | Wyeth Corp | Sulfonylated heterocycles useful for modulation of the progesterone receptor |
| PE20090159A1 (es) * | 2007-03-08 | 2009-02-21 | Plexxikon Inc | COMPUESTOS DERIVADOS DE ACIDO INDOL-PROPIONICO COMO MODULADORES PPARs |
| BRPI0914978A2 (pt) * | 2008-06-09 | 2015-10-27 | Sanofi Aventis | sulfonamidas n-heterocíclicas reforçadas com grupo principal de oxadiazolona, processos para sua preparação e seu uso como farmacêuticos |
| WO2010000353A1 (fr) * | 2008-06-09 | 2010-01-07 | Sanofi-Aventis | Sulfonamides comprenant un hétérocycle et un groupe de tête oxadiazolone, procédés pour les préparer et leur utilisation comme produits pharmaceutiques |
| CA2741125A1 (fr) | 2008-10-22 | 2010-04-29 | Merck Sharp & Dohme Corp. | Nouveaux derives de benzimidazole cycliques utiles comme agents anti-diabetiques |
| WO2010051206A1 (fr) | 2008-10-31 | 2010-05-06 | Merck Sharp & Dohme Corp. | Nouveaux agents antidiabétiques utiles avec des dérivés de benzimidazole cycliques |
| US8895596B2 (en) | 2010-02-25 | 2014-11-25 | Merck Sharp & Dohme Corp | Cyclic benzimidazole derivatives useful as anti-diabetic agents |
| US20130196990A1 (en) | 2010-10-06 | 2013-08-01 | Junya Qu | Benzimidazole Derivatives As PI3 Kinase Inhibitors |
| EP2638014B1 (fr) | 2010-11-08 | 2017-01-04 | Lycera Corporation | Tétrahydroquinolines et composés bicycliques associés n-sulphonylées pour l'inhibition de l'activité rorgamma et le traitement de maladies |
| BR112013021236B1 (pt) | 2011-02-25 | 2021-05-25 | Merck Sharp & Dohme Corp | composto derivado de benzimidazol, e, composição |
| RU2014149136A (ru) * | 2012-05-08 | 2016-07-10 | Мерк Шарп И Доум Корп. | ТЕТРАГИДРОНАФТИРИДИНОВЫЕ И РОДСТВЕННЫЕ БИЦИКЛИЧЕСКИЕ СОЕДИНЕНИЯ ДЛЯ ИНГИБИРОВАНИЯ RORγ АКТИВНОСТИ И ЛЕЧЕНИЯ ЗАБОЛЕВАНИЯ |
| JP6242868B2 (ja) * | 2012-05-08 | 2017-12-06 | リセラ・コーポレイションLycera Corporation | RORγのアゴニストとしての使用のためおよび疾患の処置のためのテトラヒドロ[1,8]ナフチリジンスルホンアミドおよび関連化合物 |
| US9527875B2 (en) | 2012-08-02 | 2016-12-27 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| MX2015010935A (es) | 2013-02-22 | 2015-10-29 | Merck Sharp & Dohme | Compuestos biciclicos antidiabeticos. |
| US9650375B2 (en) | 2013-03-14 | 2017-05-16 | Merck Sharp & Dohme Corp. | Indole derivatives useful as anti-diabetic agents |
| EP3027616B1 (fr) * | 2013-07-30 | 2018-01-10 | Boehringer Ingelheim International GmbH | Composés d'azaindole à titre de modulateurs de rorc |
| ES2811087T3 (es) | 2013-09-09 | 2021-03-10 | Vtv Therapeutics Llc | Uso de agonistas de PPAR-delta para tratar la atrofia muscular |
| WO2015051496A1 (fr) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Composés tricycliques antidiabétiques |
| CN103626767A (zh) * | 2013-12-04 | 2014-03-12 | 上海药明康德新药开发有限公司 | 区域选择性的氮杂吲哚及其合成方法 |
| WO2015095788A1 (fr) | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | Benzoxazine carbamates de 2-acylamidométhyle et de sulfonylamidométhyle pour l'inhibition de l'activité du rorgamma et le traitement d'une maladie |
| WO2015095795A1 (fr) | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | Tétrahydronaphtyridine, benzoxazine, aza-benzoxazine et composés bicycliques apparentés pour l'inhibition de l'activité de rorgamma et le traitement de maladie |
| WO2015095792A1 (fr) | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | Acides propioniques de carbamate benzoxazine et dérivés acides pour la modulation de l'activité de rorgamma et le traitement de maladie |
| US10532088B2 (en) | 2014-02-27 | 2020-01-14 | Lycera Corporation | Adoptive cellular therapy using an agonist of retinoic acid receptor-related orphan receptor gamma and related therapeutic methods |
| US9896441B2 (en) | 2014-05-05 | 2018-02-20 | Lycera Corporation | Tetrahydroquinoline sulfonamide and related compounds for use as agonists of RORγ and the treatment of disease |
| US10189777B2 (en) | 2014-05-05 | 2019-01-29 | Lycera Corporation | Benzenesulfonamido and related compounds for use as agonists of RORγ and the treatment of disease |
| CA2975997A1 (fr) | 2015-02-11 | 2016-08-18 | Merck Sharp & Dohme Corp. | Composes pyrazole substitues utilises en tant qu'inhibiteurs de rorgammat et utilisations desdits composes |
| US10421751B2 (en) | 2015-05-05 | 2019-09-24 | Lycera Corporation | Dihydro-2H-benzo[b][1,4]oxazine sulfonamide and related compounds for use as agonists of RORγ and the treatment of disease |
| WO2016201225A1 (fr) | 2015-06-11 | 2016-12-15 | Lycera Corporation | Aryl dihydro-2h-benzo[b][1,4]oxazine sulfonamide et composés apparentés destinés à être utilisés comme agonistes de rorγ et pour le traitement de maladies |
| US10287272B2 (en) | 2015-10-27 | 2019-05-14 | Merck Sharp & Dohme Corp. | Substituted indazole compounds as RORgammaT inhibitors and uses thereof |
| EP3368535B1 (fr) | 2015-10-27 | 2020-12-02 | Merck Sharp & Dohme Corp. | Acides benzoïques à substitution hétéroaryle en tant qu'inhibiteurs de rorgammat et leurs utilisations |
| WO2017075178A1 (fr) | 2015-10-27 | 2017-05-04 | Merck Sharp & Dohme Corp. | Composés pyrazoles bicycliques substitués en tant qu'inhibiteurs de rorgammat et leurs utilisations |
| EP3551176A4 (fr) | 2016-12-06 | 2020-06-24 | Merck Sharp & Dohme Corp. | Composés hétérocycliques antidiabétiques |
| WO2018118670A1 (fr) | 2016-12-20 | 2018-06-28 | Merck Sharp & Dohme Corp. | Composés de spirochromane antidiabétiques |
| CN110483509B (zh) * | 2019-09-04 | 2020-08-25 | 温州大学 | 一种合成含氮杂环衍生物的方法 |
| CN110627785B (zh) * | 2019-09-19 | 2021-06-25 | 温州大学 | 一种1,5-四氢萘啶衍生物的制备方法 |
| JP7712932B2 (ja) * | 2019-12-18 | 2025-07-24 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | Lin28の阻害剤及びその使用方法 |
| KR20230050369A (ko) * | 2020-08-07 | 2023-04-14 | 카스마 테라퓨틱스, 인코포레이티드 | Trpml 조절제 |
| CN114702448A (zh) * | 2021-09-30 | 2022-07-05 | 西南大学 | 环烯烃的三氟甲基化串联环化螺环化合物的合成方法 |
| WO2023147309A1 (fr) | 2022-01-25 | 2023-08-03 | Reneo Pharmaceuticals, Inc. | Utilisation d'agonistes ppar-delta dans le traitement d'une maladie |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2708605A1 (fr) * | 1993-07-30 | 1995-02-10 | Sanofi Sa | Dérivés du N-sulfonylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant. |
| US5795890A (en) * | 1995-09-27 | 1998-08-18 | Ono Pharmaceutical Co., Ltd. | Sulfonamide derivatives |
| FR2757157B1 (fr) * | 1996-12-13 | 1999-12-31 | Sanofi Sa | Derives d'indolin-2-one, procede pour leur preparation et compositions pharmaceutiques les contenant |
| AU2001277723A1 (en) * | 2000-08-11 | 2002-02-25 | Nippon Chemiphar Co., Ltd. | Ppardelta activators |
-
2002
- 2002-07-03 DE DE10229777A patent/DE10229777A1/de not_active Withdrawn
-
2003
- 2003-06-30 UA UAA200500952A patent/UA79003C2/uk unknown
- 2003-06-30 RU RU2005102592/04A patent/RU2328485C2/ru not_active IP Right Cessation
- 2003-06-30 MX MXPA05000133A patent/MXPA05000133A/es unknown
- 2003-06-30 HR HR20050108A patent/HRP20050108A2/hr not_active Application Discontinuation
- 2003-06-30 AU AU2003246638A patent/AU2003246638A1/en not_active Abandoned
- 2003-06-30 BR BR0312549-1A patent/BR0312549A/pt not_active IP Right Cessation
- 2003-06-30 CA CA002491477A patent/CA2491477A1/fr not_active Abandoned
- 2003-06-30 CN CNA038209446A patent/CN1678581A/zh active Pending
- 2003-06-30 WO PCT/EP2003/006896 patent/WO2004005253A1/fr not_active Ceased
- 2003-06-30 NZ NZ537486A patent/NZ537486A/en unknown
- 2003-06-30 JP JP2004518622A patent/JP2005535649A/ja not_active Withdrawn
- 2003-06-30 AR ARP030102373A patent/AR040352A1/es not_active Application Discontinuation
- 2003-06-30 US US10/519,125 patent/US20060100230A1/en not_active Abandoned
- 2003-06-30 EP EP03762547A patent/EP1519919A1/fr not_active Withdrawn
- 2003-07-01 MY MYPI20032474A patent/MY134641A/en unknown
- 2003-07-02 UY UY27878A patent/UY27878A1/es not_active Application Discontinuation
- 2003-07-02 PE PE2003000668A patent/PE20040645A1/es not_active Application Discontinuation
- 2003-07-02 HN HN2003000196A patent/HN2003000196A/es unknown
- 2003-07-02 GT GT200300135A patent/GT200300135A/es unknown
- 2003-07-02 TW TW092118027A patent/TW200418794A/zh unknown
-
2004
- 2004-12-22 IL IL16592404A patent/IL165924A0/xx unknown
-
2005
- 2005-01-03 EC EC2005005524A patent/ECSP055524A/es unknown
- 2005-01-03 MA MA28032A patent/MA27316A1/fr unknown
- 2005-01-03 ZA ZA200500013A patent/ZA200500013B/en unknown
- 2005-02-02 NO NO20050579A patent/NO20050579L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| BR0312549A (pt) | 2005-04-26 |
| ZA200500013B (en) | 2006-03-29 |
| CN1678581A (zh) | 2005-10-05 |
| NO20050579L (no) | 2005-02-02 |
| HN2003000196A (es) | 2004-11-22 |
| UA79003C2 (en) | 2007-05-10 |
| TW200418794A (en) | 2004-10-01 |
| DE10229777A1 (de) | 2004-01-29 |
| PE20040645A1 (es) | 2004-10-29 |
| RU2328485C2 (ru) | 2008-07-10 |
| JP2005535649A (ja) | 2005-11-24 |
| GT200300135A (es) | 2004-03-17 |
| IL165924A0 (en) | 2006-01-15 |
| RU2005102592A (ru) | 2005-07-10 |
| AR040352A1 (es) | 2005-03-30 |
| MY134641A (en) | 2007-12-31 |
| MXPA05000133A (es) | 2005-04-11 |
| WO2004005253A1 (fr) | 2004-01-15 |
| ECSP055524A (es) | 2005-03-10 |
| AU2003246638A1 (en) | 2004-01-23 |
| CA2491477A1 (fr) | 2004-01-15 |
| HRP20050108A2 (hr) | 2006-04-30 |
| NZ537486A (en) | 2006-07-28 |
| UY27878A1 (es) | 2004-02-27 |
| EP1519919A1 (fr) | 2005-04-06 |
| US20060100230A1 (en) | 2006-05-11 |
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| MA26729A1 (fr) | Modulateurs nouveaux des recepteurs de glucocorticoides, procede pour leur preparation et compositions pharmaceutiques les contenant | |
| MA27428A1 (fr) | Derives de pyrimidine et leur utilisation en tant que modulateurs cb2 | |
| TNSN97078A1 (fr) | Derives d'indole nouveaux, procede pour leur preparation et formulations pharmaceutiques les contenant | |
| MA27769A1 (fr) | Dérivées de 2-acylamino-4-phenylthiazole, leur préparation et leur application en thérapeutique | |
| MA27156A1 (fr) | NUCLEOSIDES 3- β-D-RIBOFURANOSYLTHIAZOLO[4,5-d] PYRIDIMINE ET LES UTILISATIONS DE CELLES-CI | |
| MA26733A1 (fr) | Derives d'isothiazole nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant | |
| RO115522B1 (ro) | Derivaţi de indolină, procedee pentru prepararea acestora, compoziţii farmaceutice care îi conţin şi metodă de tratament | |
| ATE440087T1 (de) | 2,4-diaminopyrimidinderivate, die sich als inhibitoren von pkc-theta eignen | |
| MA25035A1 (fr) | Derives de 3-azabicyclo [3,1,0] hexane nouveaux, procede pour leur preparation et compositions les contenant | |
| MA30089B1 (fr) | (arylsulfonyl)-pyrasolopiperidines | |
| MA26696A1 (fr) | Derives de tetrahydrobenzazepine nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant | |
| MA27692A1 (fr) | Composes derives de benzoxazinone, leur preparation et utilisation comme medicaments | |
| MA27676A1 (fr) | 2-amino-6-(2-substitue-4-phenoxy)-substitue-pyridines, procede pour leur preparation et compositions pharmaceutiques les contenant | |
| DE60226906D1 (de) | 3,6-disubstituierte azabicyclo ä3.1.0ühexanderivate, die sich als muscarinrezeptorantagonisten eignen | |
| TNSN00250A1 (fr) | Composes nouveaux inhibiteurs de pcp, procede pour leur preparation et compositions les contenant | |
| DE69526726D1 (de) | Tetrasubstituierte imidazolderivate, verfahren zu ihrer herstellung, ihre anwendung als medikamente und diese enthaltende pharmazeutischen zusammensetzungen |