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MA27573A1 - Sinomenine et derives de sinomenine, synthese et utilisation. - Google Patents

Sinomenine et derives de sinomenine, synthese et utilisation.

Info

Publication number
MA27573A1
MA27573A1 MA28362A MA28362A MA27573A1 MA 27573 A1 MA27573 A1 MA 27573A1 MA 28362 A MA28362 A MA 28362A MA 28362 A MA28362 A MA 28362A MA 27573 A1 MA27573 A1 MA 27573A1
Authority
MA
Morocco
Prior art keywords
sinomenin
derivatives
synthesis
sinomenine
group
Prior art date
Application number
MA28362A
Other languages
English (en)
Inventor
Guo-Wei Qin
Xi-Can Tang
Rui Wang
Tian-Xi Zhou
Pierre Lestage
Daniel-Henri Caignard
Pierre Renard
Original Assignee
Servier Lab
Shanghai Inst Materia Medica
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab, Shanghai Inst Materia Medica filed Critical Servier Lab
Publication of MA27573A1 publication Critical patent/MA27573A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SINOMENINE ET DERIVES DE SINOMENINE , SYNTHESE ET UTILISATION L'invention concerne la sinoménine et ses dérivés, ainsi que les composés de formule (I) dans laquelle - R1 représente un groupement alkyle, - R2 représente un atome d'hydrogène ou un groupement alkylcarbonyle, haloalkylcarbonyle ou arylcarbonyle - Y represent un groupe R3 ,R4, R'4, R5, R'5 et R6 sont tels que définis dans la description, - et X représente un atome d'halogène. Médicaments.
MA28362A 2002-11-28 2005-06-27 Sinomenine et derives de sinomenine, synthese et utilisation. MA27573A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CNB021538190A CN1328280C (zh) 2002-11-28 2002-11-28 汉防己碱和汉防己碱化合物,合成和应用

Publications (1)

Publication Number Publication Date
MA27573A1 true MA27573A1 (fr) 2005-10-03

Family

ID=32331921

Family Applications (1)

Application Number Title Priority Date Filing Date
MA28362A MA27573A1 (fr) 2002-11-28 2005-06-27 Sinomenine et derives de sinomenine, synthese et utilisation.

Country Status (15)

Country Link
US (1) US20060009480A1 (fr)
EP (1) EP1565444A1 (fr)
JP (1) JP2006509755A (fr)
KR (1) KR100706462B1 (fr)
CN (2) CN1328280C (fr)
AU (1) AU2003290119A1 (fr)
BR (1) BR0316609A (fr)
CA (1) CA2507067A1 (fr)
EA (1) EA200500862A1 (fr)
MA (1) MA27573A1 (fr)
MX (1) MXPA05005687A (fr)
NO (1) NO20053139L (fr)
PL (1) PL377695A1 (fr)
WO (1) WO2004048340A1 (fr)
ZA (1) ZA200504055B (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1298720C (zh) * 2005-03-18 2007-02-07 中国科学院上海有机化学研究所 C环连接有五元杂环的青藤碱衍生物和合成方法
CN1298718C (zh) * 2005-03-18 2007-02-07 中国科学院上海有机化学研究所 C环连接有吡嗪环的青藤碱衍生物、合成方法及其用途
CN100455571C (zh) * 2005-12-09 2009-01-28 湖南正清制药集团股份有限公司 青藤碱盐化合物及其制备方法
CN101578101B (zh) * 2005-12-15 2012-05-23 自然医学公司 青藤碱衍生物的制备和应用
CN100408578C (zh) * 2006-03-15 2008-08-06 南京大学 一类17-酰基青藤碱衍生物及其制备方法
EP1959956A2 (fr) * 2005-12-15 2008-08-27 Naturemed Group Corporation Derives de sinomenine et preparation et applications de ceux-ci
CN101092397B (zh) * 2006-06-19 2011-01-19 湖南正清制药集团股份有限公司 一种青藤碱结构改造化合物及其制备方法
CN1876634A (zh) * 2006-06-19 2006-12-13 湖南正清制药集团股份有限公司 一种青藤碱结构改造化合物及其制备方法
US20070290378A1 (en) * 2006-06-20 2007-12-20 International Business Machines Corporation Novel reworkable underfills for ceramic mcm c4 protection
CN100396686C (zh) * 2006-08-03 2008-06-25 西安皓天生物工程技术有限责任公司 一种汉防己甲素和汉防己乙素的制备方法
CN102093373A (zh) * 2007-06-19 2011-06-15 湖南正清制药集团股份有限公司 一种青藤碱结构改造化合物及其制备方法
EP2222643B1 (fr) * 2007-12-17 2019-03-20 SpecGx LLC Dérivés de sinoménine et procédés de synthèse
EP2398806A1 (fr) * 2009-02-23 2011-12-28 Mallinckrodt LLC (+)-morphinane n-oxydes et procédés de préparation
EP2340832A1 (fr) * 2009-12-23 2011-07-06 Universität Innsbruck Composés de morphine-6-one pour le traitement ou la prévention des maladies neurodégénératives
CN101798285B (zh) 2010-02-10 2012-05-23 中国科学院上海有机化学研究所 一种青藤碱衍生物、合成方法及其用途
CN101899004A (zh) * 2010-06-24 2010-12-01 江苏大学 青藤碱衍生物、制备方法及其医药用途
CN101948430A (zh) * 2010-09-01 2011-01-19 南京大学 青藤碱衍生物及其制备方法和应用
CN102532024B (zh) * 2011-12-28 2016-08-03 赵爱国 青藤碱衍生物
CN104306954B (zh) * 2014-09-25 2016-08-24 中山大学 Wry三肽在制备治疗阿尔茨海默症药物中的用途
CN104258371B (zh) * 2014-09-25 2016-06-15 中山大学 Www三肽在制备治疗阿尔茨海默症药物中的用途
CN104274817B (zh) * 2014-09-25 2016-06-15 中山大学 Wrw三肽在制备治疗阿尔茨海默症药物中的用途
CN104258372B (zh) * 2014-09-25 2017-01-25 中山大学 Rgd三肽在制备治疗阿尔茨海默症药物中的用途
CA3014176A1 (fr) 2016-02-10 2017-08-17 James Gray PILAAR Systeme d'attenuation acoustique gonflable ameliore
CN107648179A (zh) * 2017-09-21 2018-02-02 浙江中医药大学 一种治疗类风湿性关节炎的新型皮肤给药制剂及其制备方法
CN108704640B (zh) * 2018-06-13 2021-03-30 绍兴市梓昂新材料有限公司 一种多孔氧化铂催化剂的制备方法
CN110433132B (zh) * 2019-08-19 2023-06-30 中国人民解放军军事科学院军事医学研究院 治疗创伤后应激障碍的粉防己碱鼻用制剂
CN113880764B (zh) * 2020-07-01 2023-04-18 北京师范大学 青藤碱衍生物及其制备方法与应用
CN114831990A (zh) * 2022-03-22 2022-08-02 台州恩泽医疗中心(集团) 青藤碱在制备治疗帕金森病药物组合物中的应用
CN115260098B (zh) * 2022-06-09 2024-06-04 澳门科技大学 Abcb5抑制剂在制备多耐药性类风湿性关节炎治疗药物中的应用
CN117281801B (zh) * 2023-09-15 2025-09-02 云南贝泰妮生物科技集团股份有限公司 α-酮丁酸盐在制备预防和或治疗皮肤光老化护肤品和药物中的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4912114A (en) * 1988-03-18 1990-03-27 Sandoz Ltd. Morphinan derivatives
JP3948026B2 (ja) * 1993-07-19 2007-07-25 東レ株式会社 脳細胞保護剤
CA2318959A1 (fr) * 1998-02-20 1999-08-26 Avmax, Inc. Compose d'epimorphine et utilisation de ce dernier

Also Published As

Publication number Publication date
JP2006509755A (ja) 2006-03-23
EA200500862A1 (ru) 2005-12-29
CN1504469A (zh) 2004-06-16
CN1720232A (zh) 2006-01-11
ZA200504055B (en) 2006-08-30
CN1328280C (zh) 2007-07-25
WO2004048340A1 (fr) 2004-06-10
KR20050071712A (ko) 2005-07-07
US20060009480A1 (en) 2006-01-12
NO20053139L (no) 2005-06-27
BR0316609A (pt) 2005-10-11
WO2004048340A8 (fr) 2005-07-07
MXPA05005687A (es) 2005-08-16
CA2507067A1 (fr) 2004-06-10
KR100706462B1 (ko) 2007-04-10
EP1565444A1 (fr) 2005-08-24
AU2003290119A1 (en) 2004-06-18
PL377695A1 (pl) 2006-02-06

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