MA26627A1 - Derives de pyrazole et leurs procedes de preparation - Google Patents
Derives de pyrazole et leurs procedes de preparationInfo
- Publication number
- MA26627A1 MA26627A1 MA25567A MA25567A MA26627A1 MA 26627 A1 MA26627 A1 MA 26627A1 MA 25567 A MA25567 A MA 25567A MA 25567 A MA25567 A MA 25567A MA 26627 A1 MA26627 A1 MA 26627A1
- Authority
- MA
- Morocco
- Prior art keywords
- pyrazole derivatives
- processes
- preparation
- methods
- preparing
- Prior art date
Links
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical class C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000002829 mitogen activated protein kinase inhibitor Substances 0.000 abstract 1
- 102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 abstract 1
- 108010068338 p38 Mitogen-Activated Protein Kinases Proteins 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003217 pyrazoles Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/44—Oxygen and nitrogen or sulfur and nitrogen atoms
- C07D231/52—Oxygen atom in position 3 and nitrogen atom in position 5, or vice versa
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Obesity (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8425098P | 1998-05-05 | 1998-05-05 | |
| US12241099P | 1999-03-02 | 1999-03-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA26627A1 true MA26627A1 (fr) | 2004-12-20 |
Family
ID=26770756
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA25567A MA26627A1 (fr) | 1998-05-05 | 1999-05-03 | Derives de pyrazole et leurs procedes de preparation |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP1075467B1 (fr) |
| JP (1) | JP3590586B2 (fr) |
| KR (1) | KR100404256B1 (fr) |
| CN (1) | CN1147476C (fr) |
| AT (1) | ATE292118T1 (fr) |
| AU (1) | AU765030B2 (fr) |
| BR (1) | BR9911013A (fr) |
| CA (1) | CA2329065A1 (fr) |
| DE (1) | DE69924480D1 (fr) |
| HR (1) | HRP20000724A2 (fr) |
| HU (1) | HUP0101581A3 (fr) |
| ID (1) | ID27535A (fr) |
| IL (1) | IL139169A0 (fr) |
| MA (1) | MA26627A1 (fr) |
| NO (1) | NO317985B1 (fr) |
| NZ (1) | NZ507558A (fr) |
| PL (1) | PL344004A1 (fr) |
| RU (1) | RU2000130199A (fr) |
| TR (1) | TR200003256T2 (fr) |
| TW (1) | TW593282B (fr) |
| WO (1) | WO1999057101A1 (fr) |
| YU (1) | YU67600A (fr) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020156104A1 (en) | 1997-06-13 | 2002-10-24 | Jerry L. Adams | Novel pyrazole and pyrazoline substituted compounds |
| US7301021B2 (en) | 1997-07-02 | 2007-11-27 | Smithkline Beecham Corporation | Substituted imidazole compounds |
| US6316466B1 (en) * | 1998-05-05 | 2001-11-13 | Syntex (U.S.A.) Llc | Pyrazole derivatives P-38 MAP kinase inhibitors |
| US6858617B2 (en) | 1998-05-26 | 2005-02-22 | Smithkline Beecham Corporation | Substituted imidazole compounds |
| ES2212657T3 (es) | 1998-11-04 | 2004-07-16 | Smithkline Beecham Corporation | Pirazinas sustituidas piridin-4-il o pirimidin-4-il. |
| CA2346448A1 (fr) * | 1998-12-16 | 2000-06-22 | Warner-Lambert Company | Traitement de l'arthrite a l'aide d'inhibiteurs de la mek |
| US7125875B2 (en) | 1999-04-15 | 2006-10-24 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
| HUP0202708A3 (en) | 1999-04-15 | 2004-12-28 | Bristol Myers Squibb Co | Cyclic protein tyrosine kinase inhibitors, pharmaceutical compositions containing them and their use |
| US6399621B1 (en) | 1999-08-10 | 2002-06-04 | American Cyanamid Company | N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1, 5-α]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto |
| US6472528B1 (en) * | 1999-08-10 | 2002-10-29 | Neurocrine Biosciences, Inc. | Synthesis of substituted pyrazolopyrimidines |
| US6485746B1 (en) | 2000-08-25 | 2002-11-26 | Neurocrine Biosciences, Inc. | Controlled-release sedative-hypnotic compositions and methods related thereto |
| US6384221B1 (en) | 1999-09-02 | 2002-05-07 | Neurocrine Biosciences, Inc. | Polymorphs of N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-α]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto |
| WO2001038314A1 (fr) | 1999-11-23 | 2001-05-31 | Smithkline Beecham Corporation | Composes de 3,4-dihydro-(1h)quinazolin-2-one utilises comme inhibiteurs de kinase csbp/p38 |
| ES2249309T3 (es) | 1999-11-23 | 2006-04-01 | Smithkline Beecham Corp | Compuestos de 3,4-dihidro-(1h)quinazolin-2-ona como inhibidores de csbp/p39 kinasa. |
| ATE281439T1 (de) | 1999-11-23 | 2004-11-15 | Smithkline Beecham Corp | 3,4-dihydro-(1h)chinazolin-2-on-verbindungen als csbp/p38-kinase-inhibitoren |
| JP2004504266A (ja) * | 2000-01-17 | 2004-02-12 | バイエル アクチェンゲゼルシャフト | 置換アリールケトン類 |
| US7235551B2 (en) | 2000-03-02 | 2007-06-26 | Smithkline Beecham Corporation | 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases |
| WO2001064669A1 (fr) * | 2000-03-03 | 2001-09-07 | Pfizer Products Inc. | Derives d'ether de pyrazole utilises comme agents anti-inflammatoires/analgesiques |
| CA2876779A1 (fr) | 2000-05-12 | 2001-11-22 | Genzyme Corporation | Modulateurs de marquage du tnf-.alpha. |
| GB0016787D0 (en) | 2000-07-07 | 2000-08-30 | Pfizer Ltd | Compounds useful in therapy |
| CA2419820A1 (fr) | 2000-08-17 | 2002-02-21 | Lumera Corporation | Conception et synthese de materiaux optiques non lineaires de pointe destines a des applications electro-optiques |
| CZ20022642A3 (cs) * | 2001-08-27 | 2003-09-17 | Pfizer Products Inc. | Způsob výroby dialkylpyridylboranů |
| PL373115A1 (en) | 2001-08-30 | 2005-08-08 | F.Hoffmann-La Roche Ag | Aminopyrrole compounds as antiinflammatory agents |
| EP1534282B1 (fr) | 2002-07-09 | 2006-12-27 | Boehringer Ingelheim Pharma GmbH & Co.KG | Compositions pharmaceutiques comprenant des agents anticholinergiques etinhibiteurs de p38 kinase pour le traitement des maladies respiratoires |
| US7268139B2 (en) | 2002-08-29 | 2007-09-11 | Scios, Inc. | Methods of promoting osteogenesis |
| JPWO2004029043A1 (ja) | 2002-09-25 | 2006-01-26 | 宇部興産株式会社 | ピラゾール化合物 |
| RU2381219C2 (ru) * | 2003-06-26 | 2010-02-10 | Новартис Аг | ПРОИЗВОДНЫЕ 5-ЧЛЕННЫХ ГЕТЕРОЦИКЛОВ В КАЧЕСТВЕ ИНГИБИТОРОВ КИНАЗЫ p38 |
| PT1641764E (pt) | 2003-06-26 | 2011-10-27 | Novartis Ag | Inibidores de p38 quinase a base de heterociclo de 5 elementos |
| US7244441B2 (en) | 2003-09-25 | 2007-07-17 | Scios, Inc. | Stents and intra-luminal prostheses containing map kinase inhibitors |
| RU2419612C2 (ru) * | 2003-12-23 | 2011-05-27 | Астекс Терапьютикс Лимитед | Производные пиразола в качестве модуляторов протеинкиназы |
| BRPI0511676A (pt) * | 2004-05-29 | 2008-01-08 | 7Tm Pharma As | uso medicinal de ligandos receptores |
| US20060035893A1 (en) | 2004-08-07 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders |
| PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
| GB0513297D0 (en) * | 2005-06-29 | 2005-08-03 | Glaxo Group Ltd | Novel compounds |
| GB0603684D0 (en) * | 2006-02-23 | 2006-04-05 | Novartis Ag | Organic compounds |
| WO2008000777A2 (fr) * | 2006-06-29 | 2008-01-03 | Glaxo Group Limited | Nouveaux composés |
| GB0621978D0 (en) * | 2006-11-03 | 2006-12-13 | Chroma Therapeutics Ltd | Inhibitors of p38 mitogen-activated protein kinase |
| EP1992344A1 (fr) | 2007-05-18 | 2008-11-19 | Institut Curie | P38 alpha comme cible therapeutique pour les maladies associées á une mutation de FGFR3 |
| JP5225470B2 (ja) | 2009-08-07 | 2013-07-03 | 中外製薬株式会社 | アミノピラゾール誘導体 |
| JP2011201794A (ja) * | 2010-03-24 | 2011-10-13 | Fujifilm Corp | 5−アミノピラゾール誘導体及びその塩の製造方法 |
| JP5620417B2 (ja) * | 2011-02-07 | 2014-11-05 | 中外製薬株式会社 | アミノピラゾール誘導体を含む医薬 |
| KR102191084B1 (ko) * | 2013-09-03 | 2020-12-15 | 사름 리미티드 | 약제학적 화합물 |
| TW201609093A (zh) | 2013-12-27 | 2016-03-16 | 中外製藥股份有限公司 | Fgfr門控蛋白變異基因及以其爲標的之醫藥 |
| WO2016204261A1 (fr) | 2015-06-17 | 2016-12-22 | 中外製薬株式会社 | Dérivés d'aminopyrazole |
| GB201612240D0 (en) | 2016-07-14 | 2016-08-31 | Mereo Biopharma 1 Ltd | Method for producing a polymorphic form of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl]-n-cyclopropyl-4-methylbenzamide |
| GB201612238D0 (en) * | 2016-07-14 | 2016-08-31 | Mereo Biopharma 1 Ltd | Method for producing a polymorphic form of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-Yl]-n-cyclopropyl-4-methylbenzamide |
| WO2018059533A1 (fr) * | 2016-09-29 | 2018-04-05 | 南京明德新药研发股份有限公司 | Inhibiteur de la p38α mapk kinase, son procédé de préparation et son utilisation |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
| EP3691620B1 (fr) | 2017-10-05 | 2022-07-27 | Fulcrum Therapeutics, Inc. | Inhibiteurs de la kinase p38 réduisant l'expression du gène dux4 et des gènes aval pour le traitement de la fshd |
| EP3563848A1 (fr) * | 2018-04-30 | 2019-11-06 | S.I.S.S.A. Scuola Internazionale Superiore di Studi Avanzati | Inhibiteurs de la serpine pour le traitement des maladies à prions et de type prion |
| GB201815699D0 (en) * | 2018-09-26 | 2018-11-07 | Mereo Biopharma 1 Ltd | Synthetic method |
| GB201815695D0 (en) * | 2018-09-26 | 2018-11-07 | Mereo Biopharma 1 Ltd | Synthetic method |
| ES2974842T3 (es) * | 2018-11-13 | 2024-07-01 | Novartis Ag | Compuestos y composiciones para el tratamiento de afecciones asociadas a la actividad de nlrp |
| CN113166081A (zh) | 2018-11-13 | 2021-07-23 | 诺华股份有限公司 | 用于治疗与nlrp活性相关的病症的化合物和组合物 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69323212T2 (de) * | 1992-12-17 | 1999-05-27 | Pfizer Inc., New York, N.Y. | Pyrazole mit crf antagonistischer aktivität |
-
1999
- 1999-04-28 KR KR10-2000-7012375A patent/KR100404256B1/ko not_active Expired - Fee Related
- 1999-04-28 PL PL99344004A patent/PL344004A1/xx not_active Application Discontinuation
- 1999-04-28 HR HR20000724A patent/HRP20000724A2/hr not_active Application Discontinuation
- 1999-04-28 HU HU0101581A patent/HUP0101581A3/hu unknown
- 1999-04-28 CN CNB998060046A patent/CN1147476C/zh not_active Expired - Fee Related
- 1999-04-28 JP JP2000547071A patent/JP3590586B2/ja not_active Expired - Fee Related
- 1999-04-28 WO PCT/EP1999/002879 patent/WO1999057101A1/fr not_active Ceased
- 1999-04-28 BR BR9911013-0A patent/BR9911013A/pt not_active IP Right Cessation
- 1999-04-28 NZ NZ507558A patent/NZ507558A/en unknown
- 1999-04-28 AT AT99923484T patent/ATE292118T1/de not_active IP Right Cessation
- 1999-04-28 IL IL13916999A patent/IL139169A0/xx unknown
- 1999-04-28 AU AU40348/99A patent/AU765030B2/en not_active Ceased
- 1999-04-28 DE DE69924480T patent/DE69924480D1/de not_active Expired - Fee Related
- 1999-04-28 EP EP99923484A patent/EP1075467B1/fr not_active Expired - Lifetime
- 1999-04-28 RU RU2000130199/04A patent/RU2000130199A/ru not_active Application Discontinuation
- 1999-04-28 CA CA002329065A patent/CA2329065A1/fr not_active Abandoned
- 1999-04-28 YU YU67600A patent/YU67600A/sh unknown
- 1999-04-28 ID IDW20002241A patent/ID27535A/id unknown
- 1999-04-28 TR TR2000/03256T patent/TR200003256T2/xx unknown
- 1999-05-03 MA MA25567A patent/MA26627A1/fr unknown
- 1999-05-05 TW TW088107268A patent/TW593282B/zh not_active IP Right Cessation
-
2000
- 2000-11-02 NO NO20005535A patent/NO317985B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20010043363A (ko) | 2001-05-25 |
| ATE292118T1 (de) | 2005-04-15 |
| CA2329065A1 (fr) | 1999-11-11 |
| KR100404256B1 (ko) | 2003-11-01 |
| TW593282B (en) | 2004-06-21 |
| RU2000130199A (ru) | 2002-11-10 |
| AU4034899A (en) | 1999-11-23 |
| EP1075467B1 (fr) | 2005-03-30 |
| IL139169A0 (en) | 2001-11-25 |
| HRP20000724A2 (en) | 2001-06-30 |
| HK1037374A1 (en) | 2002-02-08 |
| HUP0101581A2 (hu) | 2002-03-28 |
| NZ507558A (en) | 2003-08-29 |
| PL344004A1 (en) | 2001-09-10 |
| AU765030B2 (en) | 2003-09-04 |
| CN1147476C (zh) | 2004-04-28 |
| CN1300282A (zh) | 2001-06-20 |
| ID27535A (id) | 2001-04-12 |
| JP2002513784A (ja) | 2002-05-14 |
| BR9911013A (pt) | 2001-02-06 |
| EP1075467A1 (fr) | 2001-02-14 |
| NO20005535D0 (no) | 2000-11-02 |
| DE69924480D1 (en) | 2005-05-04 |
| HUP0101581A3 (en) | 2002-07-29 |
| TR200003256T2 (tr) | 2001-04-20 |
| JP3590586B2 (ja) | 2004-11-17 |
| NO317985B1 (no) | 2005-01-17 |
| WO1999057101A1 (fr) | 1999-11-11 |
| YU67600A (sh) | 2003-07-07 |
| NO20005535L (no) | 2000-11-02 |
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