MA26549A1 - Medicaments - Google Patents
MedicamentsInfo
- Publication number
- MA26549A1 MA26549A1 MA25279A MA25279A MA26549A1 MA 26549 A1 MA26549 A1 MA 26549A1 MA 25279 A MA25279 A MA 25279A MA 25279 A MA25279 A MA 25279A MA 26549 A1 MA26549 A1 MA 26549A1
- Authority
- MA
- Morocco
- Prior art keywords
- drugs
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9721139.5A GB9721139D0 (en) | 1997-10-07 | 1997-10-07 | Medicaments |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA26549A1 true MA26549A1 (fr) | 2004-12-20 |
Family
ID=10820099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA25279A MA26549A1 (fr) | 1997-10-07 | 1998-10-05 | Medicaments |
Country Status (36)
| Country | Link |
|---|---|
| US (3) | US6284770B1 (fr) |
| EP (1) | EP1021174A2 (fr) |
| JP (1) | JP2001518495A (fr) |
| KR (1) | KR20010015707A (fr) |
| CN (1) | CN1281357A (fr) |
| AP (1) | AP2000001785A0 (fr) |
| AR (1) | AR017296A1 (fr) |
| AU (1) | AU750818B2 (fr) |
| BR (1) | BR9812886A (fr) |
| CA (1) | CA2305751A1 (fr) |
| CO (1) | CO5011096A1 (fr) |
| DZ (1) | DZ2618A1 (fr) |
| EA (1) | EA003184B1 (fr) |
| EE (1) | EE200000214A (fr) |
| GB (1) | GB9721139D0 (fr) |
| GT (1) | GT199800157A (fr) |
| HN (1) | HN1998000155A (fr) |
| HR (1) | HRP20000198A2 (fr) |
| HU (1) | HUP0003750A3 (fr) |
| ID (1) | ID23874A (fr) |
| IL (1) | IL135398A0 (fr) |
| IS (1) | IS5425A (fr) |
| MA (1) | MA26549A1 (fr) |
| NO (1) | NO20001776L (fr) |
| NZ (1) | NZ503698A (fr) |
| PA (1) | PA8461101A1 (fr) |
| PE (1) | PE120299A1 (fr) |
| PL (1) | PL340337A1 (fr) |
| SK (1) | SK4862000A3 (fr) |
| SV (1) | SV1998000122A (fr) |
| TN (1) | TNSN98179A1 (fr) |
| TR (1) | TR200000913T2 (fr) |
| UY (1) | UY25200A1 (fr) |
| WO (1) | WO1999017755A2 (fr) |
| YU (1) | YU20600A (fr) |
| ZA (1) | ZA989061B (fr) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9721139D0 (en) | 1997-10-07 | 1997-12-03 | Glaxo Group Ltd | Medicaments |
| US7767203B2 (en) * | 1998-08-07 | 2010-08-03 | Ganeden Biotech, Inc. | Methods for the dietary management of irritable bowel syndrome and carbohydrate malabsorption |
| US6136807A (en) * | 1998-11-10 | 2000-10-24 | 3M Innovative Properties Company | Composition for the transdermal delivery of lerisetron |
| EP1090638A1 (fr) * | 1999-10-08 | 2001-04-11 | Sanofi-Synthelabo | Utilisation de (R)-zacopride ou d'un de ses sels dans la fabrication d'un médicament pour le traitement de l'apnée du sommeil |
| TWI263496B (en) * | 1999-12-10 | 2006-10-11 | Novartis Ag | Pharmaceutical combinations and their use in treating gastrointestinal disorders |
| DE10015783C2 (de) * | 2000-03-30 | 2003-12-04 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System zur Abgabe von Lerisetron und seine Verwendung |
| JP2003533482A (ja) * | 2000-05-18 | 2003-11-11 | グラクソ グループ リミテッド | 機能性消化不良の治療方法 |
| AR028970A1 (es) * | 2000-07-26 | 2003-05-28 | Solvay Pharm Gmbh | USO DE CILANSETRON O DE SUS SALES POR ADICIoN DE A CIDOS Y/O SOLVATOS FARMACOLoGICAMENTE COMPATIBLES PARA LA OBTENCIoN DE PREPARADOS FARMACEUTICOS PARA EL TRATAMIENTO Y/O LA PROFILAXIS DEL SíNDROME DEL INTESTINO IRRITABLE |
| US6566369B2 (en) | 2000-07-26 | 2003-05-20 | Solvay Pharmaceuticals Gmbh | Medicament containing cilansetron for the treatment of non-obstipative male irritable bowel syndrome patients |
| WO2002020841A2 (fr) * | 2000-09-06 | 2002-03-14 | Glaxo Group Limited | Polymorphismes du gene du recepteur de la 5-hydroxytryptamine et reponse au traitement |
| US20040048874A1 (en) * | 2001-05-22 | 2004-03-11 | Bardsley Hazel Judith | New therapeutic use of 4-(2-fluorophenyl)-6-methyl-2-(1-piperazinyl)thieno[2,3-D]pyrimidine |
| GB0216027D0 (en) * | 2002-07-10 | 2002-08-21 | Arachnova Therapeutics Ltd | New therapeutic use |
| DK2266558T3 (en) * | 2001-06-07 | 2017-07-31 | Analgesic Neuropharmaceuticals Llc | TREATMENT OF NEUROPATHIC PAIN WITH RECEPTOR ANTAGONIST: N-METHYL-D-ASPARTATE (NMDA) |
| US7045549B2 (en) * | 2001-11-08 | 2006-05-16 | The Board Of Trustees Of The Leland Stanford Jr. University | Treatment of symptoms associated with irritable bowel syndrome |
| AU2003210610B2 (en) * | 2002-01-18 | 2007-11-29 | Aryx Therapeutics | 5-HT3 receptor antagonists and methods of use |
| WO2004004734A1 (fr) * | 2002-07-10 | 2004-01-15 | Arachnova Therapeutics Ltd. | 4-(2-fluorophenyl)-6-methyl-2(1-piperazinyl)thieno(2,3-d) pyrimidine destinee a traiter un trouble intestinal fonctionnel |
| DE10232750A1 (de) * | 2002-07-18 | 2004-02-05 | Basf Ag | Verfahren zur Herstellung von macrocyclischen Ketonen durch Dieckmann-Kondensation in der Gasphase |
| AU2003252738A1 (en) * | 2002-08-09 | 2004-02-25 | Ajinomoto Co., Inc. | Remedy for intestinal diseases and visceral pain |
| US20030187017A1 (en) * | 2002-11-14 | 2003-10-02 | Mangel Allen Wayne | Method for treating functional dyspepsia |
| CN100353946C (zh) * | 2003-01-13 | 2007-12-12 | 戴诺吉药品有限公司 | 治疗功能性肠病的方法 |
| MXPA05007379A (es) * | 2003-01-13 | 2006-02-10 | Dynogen Pharmaceuticals Inc | Metodo para tratar nauseas, vomito, esfuerzo por vomitar o cualquier combinacion de los mismos. |
| JO2735B1 (en) | 2003-01-30 | 2013-09-15 | هيلسين هيلث كير أس ايه. | Liquid pharmaceutical formations of balloonosterone |
| ZA200409537B (en) | 2003-01-31 | 2006-10-25 | Yamanouchi Pharma Co Ltd | Stable solid medicinal composition for oral administration |
| JP2007514000A (ja) * | 2003-12-16 | 2007-05-31 | テバ ファーマシューティカル インダストリーズ リミティド | テガセロッド塩基及びその塩の多形現象形 |
| WO2005073220A1 (fr) * | 2004-01-30 | 2005-08-11 | Yamanouchi Pharmaceutical Co., Ltd. | Remede contre le syndrome du colon irritable avec diarrhee |
| WO2005072730A1 (fr) * | 2004-01-30 | 2005-08-11 | Astellas Pharma Inc. | Agent therapeutique pour le syndrome de l’intestin irritable de type diarrhoe |
| JP3763360B2 (ja) * | 2004-01-30 | 2006-04-05 | アステラス製薬株式会社 | 下痢型過敏性腸症候群治療剤 |
| US7358270B2 (en) | 2004-01-30 | 2008-04-15 | Astellas Pharma Inc. | Treating agent for irritable bowel syndrome |
| MXPA06008855A (es) * | 2004-02-03 | 2007-04-17 | Univ California | Metodos para tratar sindrome de intestino irritable. |
| JP4559749B2 (ja) * | 2004-02-16 | 2010-10-13 | あすか製薬株式会社 | ピペラジニルピリジン誘導体 |
| JP4912145B2 (ja) * | 2004-02-26 | 2012-04-11 | あすか製薬株式会社 | ピリミジン誘導体 |
| JP2006028028A (ja) * | 2004-07-12 | 2006-02-02 | Teikoku Medix Kk | 経口医薬組成物 |
| US20060293309A1 (en) * | 2005-03-28 | 2006-12-28 | Dynogen Pharmaceuticals, Inc. | Method of treating disorders and conditions using peripherally-restricted antagonists and inhibitors |
| US7317022B2 (en) * | 2005-06-07 | 2008-01-08 | Theravance, Inc. | Benzoimidazolone-carboxamide compounds as 5-HT4 receptors agonists |
| WO2007000046A1 (fr) * | 2005-06-27 | 2007-01-04 | Holburn Biomedical Corporation | Methodes de diagnostic de maladie intestinale fonctionnelle |
| JP4632204B2 (ja) * | 2005-09-21 | 2011-02-16 | アステラス製薬株式会社 | 下痢型過敏性腸症候群治療剤 |
| BRPI0707979A2 (pt) * | 2006-02-20 | 2011-05-17 | Astellas Pharma Cin | derivado de amida ou sal deste |
| US7601856B2 (en) | 2006-07-27 | 2009-10-13 | Wyeth | Benzofurans as potassium ion channel modulators |
| WO2009053732A1 (fr) | 2007-10-24 | 2009-04-30 | Generics [Uk] Limited | Nouveau sel |
| WO2009053750A2 (fr) | 2007-10-24 | 2009-04-30 | Generics [Uk] Limited | Nouvelles formes cristallines et amorphes |
| WO2009053733A2 (fr) | 2007-10-24 | 2009-04-30 | Generics [Uk] Limited | Nouvelles formes cristallines |
| WO2009053754A2 (fr) | 2007-10-24 | 2009-04-30 | Generics [Uk] Limited | Nouvelles formes cristallines |
| US8734867B2 (en) | 2007-12-28 | 2014-05-27 | Liveleaf, Inc. | Antibacterial having an extract of pomegranate combined with hydrogen peroxide |
| BRPI1006287A2 (pt) | 2009-03-04 | 2015-08-25 | Metaactiv Inc | Composição botânica e aditivada por local, método de tratamento prevenção ou aperfeiçoamento dos sintomas de um distúrbio gástrico, método de tratamento da água potável, de uma infecção, de uma ferida, de desinfecção de uma superfície, de preservação de um alimento, e, de melhora da função gástrica de um animal; e kit |
| AU2010242955B2 (en) | 2009-04-29 | 2016-02-04 | Ganeden Biotech, Inc. | Inactivated bacterial cell formulation |
| WO2011001954A1 (fr) * | 2009-06-30 | 2011-01-06 | アステラス製薬株式会社 | Agent thérapeutique pour la défécation anormale chez un patient atteint d'une maladie intestinale inflammatoire en phase de rémission |
| JP5938886B2 (ja) * | 2010-12-14 | 2016-06-22 | アステラス製薬株式会社 | 活動期の炎症性腸疾患患者における排便異常治療剤 |
| US20120329736A1 (en) * | 2011-06-24 | 2012-12-27 | Huang Alexander L | Treatment for gastrointestinal disorders using a selective, site-activated binding system |
| US9192635B2 (en) | 2011-06-24 | 2015-11-24 | Liveleaf, Inc. | Method of treating damaged mucosal or gastrointestinal tissue by administering a composition comprising a mixture of pomegranate and green tea extracts and releasably bound hydrogen peroxide |
| US8722040B2 (en) | 2011-06-24 | 2014-05-13 | Liveleaf, Inc. | Site-activated binding systems that selectively increase the bioactivity of phenolic compounds at target sites |
| EP2744497B1 (fr) * | 2011-10-18 | 2016-04-06 | Helsinn Healthcare SA | Combinaisons thérapeutiques de nétupitant et de palonosétron |
| KR20200065113A (ko) * | 2012-09-05 | 2020-06-08 | 체이스 파마슈티칼스 코포레이션 | 항콜린 신경보호 조성물 및 그 방법 |
| US8716351B1 (en) | 2012-12-23 | 2014-05-06 | Liveleaf, Inc. | Methods of treating gastrointestinal spasms |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3782107T2 (de) | 1986-07-25 | 1993-04-01 | Beecham Group Plc | Azabicyclische verbindungen, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung. |
| GB8806990D0 (en) * | 1988-03-23 | 1988-04-27 | Beecham Group Plc | Novel compounds |
| GB8701022D0 (en) | 1987-01-19 | 1987-02-18 | Beecham Group Plc | Treatment |
| ATE111910T1 (de) | 1987-09-03 | 1994-10-15 | Glaxo Group Ltd | Lactamderivate. |
| EP0315390B1 (fr) | 1987-11-04 | 1994-07-20 | Beecham Group Plc | Composés nouveaux de 4-oxobenzotriazine et 4-oxoquinazoline |
| JPH0249772A (ja) * | 1988-04-07 | 1990-02-20 | Glaxo Group Ltd | イミダゾール誘導体 |
| GB8814277D0 (en) | 1988-06-16 | 1988-07-20 | Glaxo Group Ltd | Chemical compounds |
| NZ230068A (en) * | 1988-07-29 | 1991-07-26 | Dainippon Pharmaceutical Co | Indazole-3-carboxylic acid esters and amides of diaza compounds having 6,7, or 8 ring members: preparatory processes and pharmaceutical compositions |
| GB8820650D0 (en) * | 1988-09-01 | 1988-10-05 | Glaxo Group Ltd | Medicaments |
| GB8823980D0 (en) * | 1988-10-13 | 1988-11-23 | Glaxo Group Ltd | Chemical compounds |
| GB8829079D0 (en) | 1988-12-13 | 1989-01-25 | Beecham Group Plc | Novel compounds |
| GB8904551D0 (en) * | 1989-02-28 | 1989-04-12 | Glaxo Group Ltd | Chemical compounds |
| EP0387431A1 (fr) * | 1989-03-14 | 1990-09-19 | Beecham Group Plc | Dérivés d'imidazole, procédés de leur préparation et leur application comme produits pharmaceutiques |
| GB9020927D0 (en) * | 1990-09-26 | 1990-11-07 | Beecham Group Plc | Pharmaceuticals |
| GB9027098D0 (en) * | 1990-12-13 | 1991-02-06 | Beecham Group Plc | Pharmaceuticals |
| GB9027487D0 (en) * | 1990-12-19 | 1991-02-06 | Beecham Group Plc | Pharmaceuticals |
| JPH06506443A (ja) * | 1991-01-09 | 1994-07-21 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | アザ二環式およびアザ三環式誘導体、その製法および中間体ならびに該化合物含有の医薬組成物 |
| GB9214184D0 (en) | 1992-07-03 | 1992-08-12 | Smithkline Beecham Plc | Pharmaceuticals |
| GB9721139D0 (en) * | 1997-10-07 | 1997-12-03 | Glaxo Group Ltd | Medicaments |
-
1997
- 1997-10-07 GB GBGB9721139.5A patent/GB9721139D0/en not_active Ceased
-
1998
- 1998-10-05 HU HU0003750A patent/HUP0003750A3/hu unknown
- 1998-10-05 KR KR1020007003739A patent/KR20010015707A/ko not_active Withdrawn
- 1998-10-05 WO PCT/EP1998/006278 patent/WO1999017755A2/fr not_active Ceased
- 1998-10-05 SK SK486-2000A patent/SK4862000A3/sk unknown
- 1998-10-05 AP AP2000001785A patent/AP2000001785A0/xx unknown
- 1998-10-05 PL PL98340337A patent/PL340337A1/xx unknown
- 1998-10-05 AR ARP980104959A patent/AR017296A1/es not_active Application Discontinuation
- 1998-10-05 ZA ZA9809061A patent/ZA989061B/xx unknown
- 1998-10-05 PE PE1998000940A patent/PE120299A1/es not_active Application Discontinuation
- 1998-10-05 HR HR20000198A patent/HRP20000198A2/hr not_active Application Discontinuation
- 1998-10-05 US US09/529,050 patent/US6284770B1/en not_active Expired - Lifetime
- 1998-10-05 CA CA002305751A patent/CA2305751A1/fr not_active Abandoned
- 1998-10-05 IL IL13539898A patent/IL135398A0/xx unknown
- 1998-10-05 CN CN98811899A patent/CN1281357A/zh active Pending
- 1998-10-05 JP JP2000514627A patent/JP2001518495A/ja active Pending
- 1998-10-05 AU AU96293/98A patent/AU750818B2/en not_active Ceased
- 1998-10-05 TN TNTNSN98179A patent/TNSN98179A1/fr unknown
- 1998-10-05 MA MA25279A patent/MA26549A1/fr unknown
- 1998-10-05 PA PA19988461101A patent/PA8461101A1/es unknown
- 1998-10-05 EA EA200000299A patent/EA003184B1/ru not_active IP Right Cessation
- 1998-10-05 BR BR9812886-8A patent/BR9812886A/pt not_active IP Right Cessation
- 1998-10-05 ID IDW20000654A patent/ID23874A/id unknown
- 1998-10-05 TR TR2000/00913T patent/TR200000913T2/xx unknown
- 1998-10-05 YU YU20600A patent/YU20600A/sh unknown
- 1998-10-05 EE EEP200000214A patent/EE200000214A/xx unknown
- 1998-10-05 EP EP98950103A patent/EP1021174A2/fr not_active Withdrawn
- 1998-10-05 NZ NZ503698A patent/NZ503698A/xx unknown
- 1998-10-06 SV SV1998000122A patent/SV1998000122A/es unknown
- 1998-10-06 CO CO98057956A patent/CO5011096A1/es unknown
- 1998-10-06 DZ DZ980228A patent/DZ2618A1/fr active
- 1998-10-06 HN HN1998000155A patent/HN1998000155A/es unknown
- 1998-10-07 GT GT199800157A patent/GT199800157A/es unknown
- 1998-10-07 UY UY25200A patent/UY25200A1/es not_active Application Discontinuation
-
2000
- 2000-03-31 IS IS5425A patent/IS5425A/is unknown
- 2000-04-06 NO NO20001776A patent/NO20001776L/no not_active Application Discontinuation
-
2001
- 2001-04-13 US US09/834,717 patent/US6429209B2/en not_active Expired - Fee Related
-
2002
- 2002-06-10 US US10/166,401 patent/US6593336B2/en not_active Expired - Lifetime
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