MA26457A1 - Vinylpyrrolidone-cephalosporines a substituants basiques, procede pour leur preparation, compositions pharmaceutiques les contenant et leur utilisation - Google Patents

Vinylpyrrolidone-cephalosporines a substituants basiques, procede pour leur preparation, compositions pharmaceutiques les contenant et leur utilisation

Info

Publication number: MA26457A1
Authority: MA; Morocco
Prior art keywords: hydrogen; formula; hydroxy; ylmethyl; omega
Prior art date: 1996-12-19

Application number

MA24904A

Other languages

English (en)

Inventor

Hebeisen Paul

Page Malcolm

Runtz Valerie

Angehrn Peter

Heinze-Krauss Ingrid

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-12-19

Filing date

1997-12-18

Publication date

2004-12-20

1997-12-18 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2004-12-20 Publication of MA26457A1 publication Critical patent/MA26457A1/fr

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Communicable Diseases (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Cephalosporin Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)
Peptides Or Proteins (AREA)

MA24904A 1996-12-19 1997-12-18 Vinylpyrrolidone-cephalosporines a substituants basiques, procede pour leur preparation, compositions pharmaceutiques les contenant et leur utilisation MA26457A1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP96120472		1996-12-19
EP97119528		1997-11-07

Publications (1)

Publication Number	Publication Date
MA26457A1 true MA26457A1 (fr)	2004-12-20

Family

ID=26142379

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA24904A MA26457A1 (fr)	1996-12-19	1997-12-18	Vinylpyrrolidone-cephalosporines a substituants basiques, procede pour leur preparation, compositions pharmaceutiques les contenant et leur utilisation

Country Status (20)

Country	Link
US (1)	US5981519A (fr)
EP (1)	EP0849269B9 (fr)
JP (2)	JP3264877B2 (fr)
KR (3)	KR100395985B1 (fr)
CN (5)	CN1183141C (fr)
AT (1)	ATE220402T1 (fr)
AU (1)	AU729653B2 (fr)
CA (2)	CA2224438C (fr)
CY (1)	CY2400B1 (fr)
CZ (1)	CZ405797A3 (fr)
DE (1)	DE69713865T2 (fr)
DK (1)	DK0849269T3 (fr)
ES (1)	ES2179996T3 (fr)
HU (1)	HUP9702474A3 (fr)
IL (1)	IL122604A0 (fr)
MA (1)	MA26457A1 (fr)
NO (1)	NO975901L (fr)
NZ (1)	NZ329363A (fr)
PT (1)	PT849269E (fr)
TW (1)	TW415949B (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5977381A (en) *	1998-01-12	1999-11-02	Hoffmann-La Roche Inc.	Process for making 3-amino-pyrolidine derivatives
BRPI9911178C1 (pt) *	1998-06-15	2021-05-25	Basilea Pharmaceutica Ag	derivados de 3-(2-oxo-[1,3']bipirrolidinil-3-ilidenometil)-cefems, bem como preparação farmacêutica e uso dos mesmos
US6232306B1 (en) *	1998-06-15	2001-05-15	Hoffmann-La Roche Inc.	Derivatives of 3-(2-oxo-[1,3′]bipyrrolidinyl-3-ylidenemethyl)-cephams
WO2000032605A1 (fr) *	1998-12-03	2000-06-08	F. Hoffmann-La Roche Ag	Bi-pyrrolidinylvinyl (carba) cephalosporines
DE60035925T2 (de) *	1999-07-05	2008-05-15	Basilea Pharmaceutica Ag	Verfahren zur Herstellung von Cephalosporin-Derivaten
AU6267100A (en) *	1999-07-07	2001-01-30	F. Hoffmann-La Roche Ag	Vinylpyrrolidinone derivatives with substituted thiazole ring
ATE341642T1 (de)	2000-04-19	2006-10-15	Basilea Pharmaceutica Ag	Verfahren zur herstellung von d- asparaginderivaten
US6504025B2 (en)	2000-05-24	2003-01-07	Basilea Pharmaceutica Ag	Process for the preparation of vinyl-pyrrolidinone cephalosporin derivatives
CN1212327C (zh) *	2000-08-14	2005-07-27	巴斯利尔药物股份公司	N－保护的－3－吡咯烷－内酰胺取代的鏻盐的制备
ITMI20012363A1 (it) *	2001-11-09	2003-05-09	Antibioticos Spa	Metodo per la sintesi di catene laterali di cefalosporine
EP1606293B1 (fr)	2003-03-27	2009-08-19	Basilea Pharmaceutica AG	Cephalosporine sous forme cristalline
EP2308562B1 (fr) *	2003-12-25	2015-02-25	Ono Pharmaceutical Co., Ltd.	Composes cycliques d'azetidine et medicaments les renfermant
US7569691B2 (en) *	2005-04-20	2009-08-04	Shin-Etsu Chemical Co., Ltd.	Protected piperazino group-bearing organoxysilane compound and making method
CN101245079B (zh) *	2007-02-14	2010-07-07	山东轩竹医药科技有限公司	头孢抗生素衍生物
CN101245077B (zh) *	2007-02-14	2010-06-02	山东轩竹医药科技有限公司	头孢菌素衍生物
EP2205600A1 (fr)	2007-10-25	2010-07-14	Achaogen, Inc.	Antibiotiques bêta-lactames à carbacéphème
AR071318A1 (es)	2008-04-15	2010-06-09	Basilea Pharmaceutica Ag	Benzhidril ester del acido (6r,7r)-7-{2-(5-amino-[1,2,4]tiadiazol-3-il)-2-[(z)-tritiloxiimino]-acetilamino}-3-[(r)-1'-terc-butoxicarbonil-2-oxo-[1,3']bipirrolidinil-(3e)-ilidenometil]-8-oxo-5-tia-1-aza-biciclo[4.2.0]oct-2-eno-2-carboxilico cristalino; su elaboracion y uso
WO2010030810A1 (fr) *	2008-09-10	2010-03-18	Achaogen, Inc.	Antibiotiques de type béta-lactame à base de carbacéphème
WO2010072672A1 (fr)	2008-12-24	2010-07-01	Basilea Pharmaceutica Ag	Nouveaux polymorphes cristallins du ceftobiprole
CN101899059B (zh) *	2009-01-21	2012-02-15	山东轩竹医药科技有限公司	含有吡咯烷并环的头孢菌素衍生物
US9139597B2 (en)	2009-05-25	2015-09-22	Sandoz Ag	Method for the production of ceftobiprole medocaril
CN102030766B (zh) *	2009-09-30	2012-08-08	山东轩竹医药科技有限公司	含有二氢吡咯并杂环的头孢抗生素
CN103864851B (zh) *	2014-03-25	2016-08-17	华润赛科药业有限责任公司	作为前药的头孢吡普衍生物及其制备方法和用途
CA3268414A1 (fr)	2022-10-10	2024-04-18	Basilea Pharmaceutica International Ag, Allschwil	Méthodes de traitement d'infections avec bactériémie à staphylococcus aureus

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL94946A0 (en) *	1989-07-13	1991-06-10	Eisai Co Ltd	3-substituted vinyl cephalosporin derivatives,their preparation and pharmaceutical compositions containing them
KR950704331A (ko) *	1992-07-12	1995-11-17	후지야마 아키라	세펨 화합물 및 그의 약제학적 조성물(cephem compounds and their pharmaceutical compositions)
US5523400A (en) *	1993-04-16	1996-06-04	Hoffmann-La Roche Inc.	Cephalosporin antibiotics
EP0620225B1 (fr) *	1993-04-16	2002-11-13	Basilea Pharmaceutica AG	Dérivés de céphalosporine
ES2157989T3 (es) *	1993-09-29	2001-09-01	Meiji Seika Kaisha	Nuevos derivados de cefalosporina.
JPH11501017A (ja)	1995-02-27	1999-01-26	エフ・ホフマン−ラロシュアーゲー	３−ピロリジリデン−２−オン−セファロスポリンの誘導体
JPH08319291A (ja) *	1995-05-25	1996-12-03	Meiji Seika Kaisha Ltd	新規セフェム誘導体
AT403161B (de) *	1995-07-19	1997-11-25	Biochemie Gmbh	Verfahren zur herstellung von cephemverbindungen

1997
- 1997-12-01 TW TW086118048A patent/TW415949B/zh not_active IP Right Cessation
- 1997-12-08 US US08/986,549 patent/US5981519A/en not_active Expired - Lifetime
- 1997-12-09 NZ NZ329363A patent/NZ329363A/xx unknown
- 1997-12-10 CA CA002224438A patent/CA2224438C/fr not_active Expired - Lifetime
- 1997-12-10 CA CA2628224A patent/CA2628224C/fr not_active Expired - Lifetime
- 1997-12-11 AT AT97121833T patent/ATE220402T1/de active
- 1997-12-11 ES ES97121833T patent/ES2179996T3/es not_active Expired - Lifetime
- 1997-12-11 PT PT97121833T patent/PT849269E/pt unknown
- 1997-12-11 EP EP97121833A patent/EP0849269B9/fr not_active Expired - Lifetime
- 1997-12-11 DK DK97121833T patent/DK0849269T3/da active
- 1997-12-11 DE DE69713865T patent/DE69713865T2/de not_active Expired - Lifetime
- 1997-12-15 IL IL12260497A patent/IL122604A0/xx unknown
- 1997-12-15 HU HU9702474A patent/HUP9702474A3/hu unknown
- 1997-12-16 NO NO975901A patent/NO975901L/no not_active Application Discontinuation
- 1997-12-17 CZ CZ974057A patent/CZ405797A3/cs unknown
- 1997-12-17 KR KR1019970069917A patent/KR100395985B1/ko not_active Expired - Lifetime
- 1997-12-18 CN CNB001337637A patent/CN1183141C/zh not_active Expired - Lifetime
- 1997-12-18 MA MA24904A patent/MA26457A1/fr unknown
- 1997-12-18 CN CNB001337629A patent/CN1163496C/zh not_active Expired - Lifetime
- 1997-12-18 AU AU48463/97A patent/AU729653B2/en not_active Expired
- 1997-12-18 CN CN97120875A patent/CN1104436C/zh not_active Expired - Lifetime
- 1997-12-19 JP JP35041397A patent/JP3264877B2/ja not_active Expired - Lifetime
2000
- 2000-11-03 CN CN00133761A patent/CN1132833C/zh not_active Expired - Lifetime
- 2000-11-03 CN CNB001337645A patent/CN1198833C/zh not_active Expired - Lifetime
2001
- 2001-03-29 KR KR1020010016369A patent/KR100310384B1/ko not_active Expired - Lifetime
- 2001-03-29 KR KR1020010016370A patent/KR100331212B1/ko not_active Expired - Lifetime
- 2001-05-28 JP JP2001158260A patent/JP4043203B2/ja not_active Expired - Fee Related
2003
- 2003-12-31 CY CY0300097A patent/CY2400B1/xx unknown

Also Published As

Publication number	Publication date
JP3264877B2 (ja)	2002-03-11
HUP9702474A3 (en)	2001-04-28
DE69713865T2 (de)	2003-02-20
JP2002060390A (ja)	2002-02-26
CN1325850A (zh)	2001-12-12
EP0849269A1 (fr)	1998-06-24
CN1347882A (zh)	2002-05-08
KR19980064240A (ko)	1998-10-07
EP0849269B9 (fr)	2003-03-05
PT849269E (pt)	2002-11-29
CN1198833C (zh)	2005-04-27
KR100310384B1 (ko)	2001-11-08
CN1183141C (zh)	2005-01-05
CN1132833C (zh)	2003-12-31
JPH10182657A (ja)	1998-07-07
DK0849269T3 (da)	2002-10-28
NO975901L (no)	1998-06-22
CN1347884A (zh)	2002-05-08
AU4846397A (en)	1998-06-25
CA2628224C (fr)	2010-02-16
CA2224438A1 (fr)	1998-06-19
IL122604A0 (en)	1998-08-16
CN1104436C (zh)	2003-04-02
ES2179996T3 (es)	2003-02-01
TW415949B (en)	2000-12-21
CN1347883A (zh)	2002-05-08
CA2628224A1 (fr)	1998-06-19
EP0849269B1 (fr)	2002-07-10
ATE220402T1 (de)	2002-07-15
HU9702474D0 (en)	1998-03-02
CN1163496C (zh)	2004-08-25
CA2224438C (fr)	2009-02-24
JP4043203B2 (ja)	2008-02-06
US5981519A (en)	1999-11-09
DE69713865D1 (de)	2002-08-14
NZ329363A (en)	1999-01-28
KR100331212B1 (ko)	2002-04-03
CZ405797A3 (cs)	1998-07-15
KR100395985B1 (ko)	2004-02-14
CN1188112A (zh)	1998-07-22
CY2400B1 (en)	2004-09-10
HUP9702474A2 (hu)	1998-11-30
NO975901D0 (no)	1997-12-16
AU729653B2 (en)	2001-02-08

Publication	Publication Date	Title
MA26457A1 (fr)	2004-12-20	Vinylpyrrolidone-cephalosporines a substituants basiques, procede pour leur preparation, compositions pharmaceutiques les contenant et leur utilisation
HUT56370A (en)	1991-08-28	Process for producing tricyclic carbapenem derivatives and pharmaceutical compositions comprising such compounds as active ingredient
DE68917023D1 (de)	1994-09-01	3-Pyrrolidinylthio-1-azabicyclo[3.2.0]-hept-2-en-2-carbonsäureverbindungen.
TW375615B (en)	1999-12-01	Galanthamine derivatives and their use as medicaments
AU636351B2 (en)	1993-04-29	N-heteroaryl-purin-6-amines, a process for their preparation and their use as medicaments
ES2013403A6 (es)	1990-05-01	Procedimiento para preparar derivados de cefem.
AU626740B2 (en)	1992-08-06	Aminocarbonylcarbamates related to physostigmine, a process for their preparation and their use as medicaments
MY111702A (en)	2000-11-30	5-amino-8-methyl-7-pyrrolidinylquinoline-3-carboxylic acid derivative
IL122664A0 (en)	1998-08-16	Esters and amides as PLA2 inhibitors
HUT50352A (en)	1990-01-29	Process for producing new antiviral prine derivatives and pharmaceutical compositions comprising same
ATE212637T1 (de)	2002-02-15	Anitbiotisch wirksame cephalosporine und verfahren zu ihrer herstellung
BRPI9705650A (pt)	1999-05-25	derivados de cefalosporinas, bem como processo para a fabricação , preparação farmacêutica e uso dos mesmos.
HU904214D0 (en)	1990-12-28	Process for producing pyrrolo(2,1-b)thiazole derivatives
AU4878479A (en)	1980-01-17	Clavulanic acid derivatives