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MA25984A1 - Procede pour preparation de maleate d'amlodipine. - Google Patents

Procede pour preparation de maleate d'amlodipine.

Info

Publication number
MA25984A1
MA25984A1 MA27182A MA27182A MA25984A1 MA 25984 A1 MA25984 A1 MA 25984A1 MA 27182 A MA27182 A MA 27182A MA 27182 A MA27182 A MA 27182A MA 25984 A1 MA25984 A1 MA 25984A1
Authority
MA
Morocco
Prior art keywords
preparation
amlodipine maleate
amlodipine
maleate
Prior art date
Application number
MA27182A
Other languages
English (en)
Inventor
Frantisek Picha
Pavel Slanina
Franciscus Bernardus Benneker
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29740325&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA25984(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Publication of MA25984A1 publication Critical patent/MA25984A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
MA27182A 2000-12-29 2003-05-27 Procede pour preparation de maleate d'amlodipine. MA25984A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25861200P 2000-12-29 2000-12-29
US80934301A 2001-03-16 2001-03-16
BE2001/0709A BE1014452A6 (nl) 2000-12-29 2001-11-05 Werkwijze voor het maken van amlodipinemaleaat.

Publications (1)

Publication Number Publication Date
MA25984A1 true MA25984A1 (fr) 2003-12-31

Family

ID=29740325

Family Applications (1)

Application Number Title Priority Date Filing Date
MA27182A MA25984A1 (fr) 2000-12-29 2003-05-27 Procede pour preparation de maleate d'amlodipine.

Country Status (24)

Country Link
US (2) US6600047B2 (fr)
EP (1) EP1309555B1 (fr)
CN (1) CN1272319C (fr)
AP (1) AP2003002820A0 (fr)
AT (3) ATE300520T1 (fr)
BE (1) BE1014452A6 (fr)
BR (1) BR0116557A (fr)
CA (1) CA2433288C (fr)
DE (2) DE60112305T2 (fr)
DK (3) DK1309555T3 (fr)
ES (1) ES2243553T3 (fr)
FI (1) FI6788U1 (fr)
HR (1) HRP20030526A2 (fr)
IL (1) IL156692A0 (fr)
IS (1) IS6834A (fr)
MA (1) MA25984A1 (fr)
MX (1) MXPA03005885A (fr)
NO (1) NO20032518L (fr)
NZ (1) NZ526506A (fr)
PL (1) PL362660A1 (fr)
PT (1) PT1309555E (fr)
RS (1) RS53403A (fr)
SI (1) SI1309555T1 (fr)
WO (1) WO2002053542A1 (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6653481B2 (en) * 2000-12-29 2003-11-25 Synthon Bv Process for making amlodipine
WO2002053541A1 (fr) * 2000-12-29 2002-07-11 Pfizer Limited Derive d'amide d'amlodipine
MXPA03005882A (es) * 2000-12-29 2005-04-19 Pfizer Ltd Derivado amida de amlodipina.
IL156692A0 (en) 2000-12-29 2004-01-04 Pfizer Ltd Process for making amlodipine maleate
WO2002053540A1 (fr) * 2000-12-29 2002-07-11 Pfizer Limited Derive aspartate de l'amlodipine utilise comme antagoniste des canaux calciques
GB0114709D0 (en) * 2001-06-15 2001-08-08 Pfizer Ltd Stabilised formulations of amlodipine maleate
US20030027848A1 (en) * 2001-06-15 2003-02-06 Anne Billotte Stabilized formulations
US20030180354A1 (en) * 2001-10-17 2003-09-25 Dr. Reddy's Laboratories Limited Amlodipine maleate formulations
KR100496436B1 (ko) 2002-07-30 2005-06-20 씨제이 주식회사 암로디핀의 유기산염
KR100538641B1 (ko) * 2002-07-30 2005-12-22 씨제이 주식회사 암로디핀의 유기산염
KR100467669B1 (ko) * 2002-08-21 2005-01-24 씨제이 주식회사 암로디핀의 유기산염
AU2003253460A1 (en) 2002-09-19 2004-04-08 Cj Corporation Crystalline organic acid salt of amlodipine
EP1407773A1 (fr) * 2002-10-08 2004-04-14 Council of Scientific and Industrial Research Procede pour la preparation des sels de s(-)amlodipine
US20040072879A1 (en) * 2002-10-10 2004-04-15 Dr. Reddy's Laboratories Limited Crystalline 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine maleate salt (Amlodipine)
AU2002368531A1 (en) * 2002-12-30 2004-07-22 Eos Eczacibasi Ozgun Kimyasal Urunler Sanayi Ve Ticaret A.S. Isolation of dihydropyridine derivative and preparation salts thereof
WO2005023769A1 (fr) * 2003-09-04 2005-03-17 Cipla Limited Procede pour l'elaboration de sels d'amlodipine
CN1882543A (zh) * 2003-11-20 2006-12-20 科学与工业研究委员会 制备手性氨氯地平盐的方法
US20060035940A1 (en) * 2004-03-16 2006-02-16 Sepracor Inc. (S)-Amlodipine malate
ES2382055T3 (es) * 2006-11-02 2012-06-04 Millennium Pharmaceuticals, Inc. Métodos para sintetizar sales farmacéuticas de un inhibidor del factor Xa
KR100843400B1 (ko) * 2006-11-14 2008-07-04 씨제이제일제당 (주) 결정성 ｓ-(-)-암로디핀 말레익산 염 무수물 및 이의제조방법
US20090062352A1 (en) * 2007-08-29 2009-03-05 Protia, Llc Deuterium-enriched amlodipine
CN102344409B (zh) * 2011-07-20 2013-04-03 海南锦瑞制药股份有限公司 一种氨氯地平晶体、其与贝那普利药用组合物及制备方法
CN102382041B (zh) * 2011-12-02 2016-01-20 东北制药集团股份有限公司 一种马来酸氨氯地平的制备方法
CN103044314A (zh) * 2013-01-06 2013-04-17 先声药业有限公司 马来酸氨氯地平的制备方法
CN104529877A (zh) * 2015-01-22 2015-04-22 华东理工常熟研究院有限公司 氨氯地平-癸酸离子液体及其制备方法和用途
EP4585213A3 (fr) 2016-10-07 2025-10-08 Silvergate Pharmaceuticals, Inc. Formulations d'amlodipine
CN108358833A (zh) * 2018-03-15 2018-08-03 上海峰林生物科技有限公司 一种马来酸氨氯地平的合成工艺
JP7456933B2 (ja) 2018-04-11 2024-03-27 シルバーゲイト ファーマシューティカルズ，インク． アムロジピン製剤
CN109651236A (zh) * 2019-01-24 2019-04-19 浙江尖峰药业有限公司 门冬氨酸氨氯地平的晶型及其制备和应用

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4294969A (en) * 1979-01-29 1981-10-13 Merck & Co., Inc. Process for producing 2-bromo-3,5-disubstituted pyridines
CS228917B2 (en) * 1981-03-14 1984-05-14 Pfizer Method of preparing substituted derivatives of 1,4-dihydropyridine
DK161312C (da) * 1982-03-11 1991-12-09 Pfizer Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden
GR851819B (fr) * 1984-08-17 1985-11-26 Wyeth John & Brother Ltd
IT1201454B (it) * 1985-08-19 1989-02-02 Boehringer Biochemia Srl 1,4-diidropiridine-2-sostituite
GB8608335D0 (en) 1986-04-04 1986-05-08 Pfizer Ltd Pharmaceutically acceptable salts
US4983740A (en) 1986-08-04 1991-01-08 Adir Et Compagnie Process for 1,4-dihydropyridine compounds
FR2602231B1 (fr) * 1986-08-04 1988-10-28 Adir Nouveaux derives de la dihydro-1,4 pyridine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
GB8710493D0 (en) 1987-05-02 1987-06-03 Pfizer Ltd Dihydropyridines
US5155120A (en) 1991-01-14 1992-10-13 Pfizer Inc Method for treating congestive heart failure
WO1993006082A1 (fr) 1991-09-13 1993-04-01 Merck & Co., Inc. Procede de preparation de 1,4-dihyropyridines-4-substitues
US5389654A (en) 1992-11-26 1995-02-14 Lek, Tovarna, Farmacevtskih In Kemicnih . . . 3-ethyl 5-methyl(±)2-[2-(N-tritylamino)ethoxymethyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-6-methyl-3,5-pyridinedicarboxylate
HU221810B1 (hu) 1997-08-12 2003-01-28 EGIS Gyógyszergyár Rt. Eljárás amlodipin-bezilát előállítására és az eljárás intermedierjei
ZA9810320B (en) 1997-11-14 2000-05-11 Gea Farmaceutisk Fabrik As Process for the preparation of 1,4-dihydropyridines and novel compounds of use for such purpose.
ZA9810319B (en) * 1997-11-14 2000-05-11 Gea Farmaceutisk Fabrik As Process for the preparation of acetal derivatives of 1,4-dihydropyridines, novel acetal derivatives and the use of the acetal derivatives for the preparation of other 1,4-dihydropyridines.
PL189666B1 (pl) * 1998-04-09 2005-09-30 Adamed Sp Z Oo Sposób otrzymywania benzenosulfonianu amlodypiny
GB9812413D0 (en) 1998-06-10 1998-08-05 Glaxo Group Ltd Compound and its use
ES2151850B1 (es) 1998-10-26 2001-08-16 Esteve Quimica Sa Intermedio para la sintesis de amlodipino para su obtencion y utilizacion correspondiente.
GB9827387D0 (en) 1998-12-11 1999-02-03 Smithkline Beecham Plc Novel process
GB9827431D0 (en) 1998-12-11 1999-02-03 Smithkline Beecham Plc Novel compound
EP1309556B1 (fr) * 2000-12-29 2004-11-24 Pfizer Limited Fumarate d'amlodipine
IL156692A0 (en) 2000-12-29 2004-01-04 Pfizer Ltd Process for making amlodipine maleate
WO2002053541A1 (fr) * 2000-12-29 2002-07-11 Pfizer Limited Derive d'amide d'amlodipine
DE60116514T2 (de) * 2000-12-29 2006-08-17 Pfizer Ltd., Sandwich Amlodipinhemimaleat
WO2002053540A1 (fr) * 2000-12-29 2002-07-11 Pfizer Limited Derive aspartate de l'amlodipine utilise comme antagoniste des canaux calciques

Also Published As

Publication number Publication date
EP1309555A1 (fr) 2003-05-14
BR0116557A (pt) 2003-10-28
FIU20030476U0 (fi) 2003-12-17
CN1505614A (zh) 2004-06-16
NZ526506A (en) 2004-11-26
PT1309555E (pt) 2005-10-31
DE60112305D1 (de) 2005-09-01
SI1309555T1 (sl) 2005-12-31
US20030199559A1 (en) 2003-10-23
US6600047B2 (en) 2003-07-29
AP2003002820A0 (en) 2003-06-30
EP1309555B1 (fr) 2005-07-27
NO20032518L (no) 2003-06-26
AT7109U3 (de) 2005-05-25
AT7110U2 (de) 2004-10-25
BE1014452A6 (nl) 2003-10-07
AT7110U3 (de) 2005-05-25
AT7110U9 (de) 2004-11-25
NO20032518D0 (no) 2003-06-04
CA2433288C (fr) 2006-06-13
HRP20030526A2 (en) 2005-06-30
WO2002053542A1 (fr) 2002-07-11
DK200300344U1 (da) 2003-12-12
HK1064671A1 (en) 2005-02-04
ATE300520T1 (de) 2005-08-15
DK200300345U3 (da) 2004-03-12
IS6834A (is) 2003-05-30
MXPA03005885A (es) 2005-04-19
RS53403A (sr) 2006-10-27
US20020086888A1 (en) 2002-07-04
DK1309555T3 (da) 2005-10-24
CN1272319C (zh) 2006-08-30
ES2243553T3 (es) 2005-12-01
FI6788U1 (fi) 2005-09-14
PL362660A1 (en) 2004-11-02
HK1055965A1 (en) 2004-01-30
IL156692A0 (en) 2004-01-04
CA2433288A1 (fr) 2002-07-11
DE20115704U1 (de) 2002-02-14
AT7109U2 (de) 2004-10-25
DE60112305T2 (de) 2006-05-24
DK200300344U4 (da) 2005-09-09

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