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MA22923A1 - Procede de preparation de nouveaux composes . - Google Patents

Procede de preparation de nouveaux composes .

Info

Publication number
MA22923A1
MA22923A1 MA23149A MA23149A MA22923A1 MA 22923 A1 MA22923 A1 MA 22923A1 MA 23149 A MA23149 A MA 23149A MA 23149 A MA23149 A MA 23149A MA 22923 A1 MA22923 A1 MA 22923A1
Authority
MA
Morocco
Prior art keywords
preparation
new compounds
compounds
new
Prior art date
Application number
MA23149A
Other languages
English (en)
Inventor
Benjamin Christensen Siegrfied
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of MA22923A1 publication Critical patent/MA22923A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C255/46—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D303/46—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals by amide or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
MA23149A 1992-04-02 1993-04-01 Procede de preparation de nouveaux composes . MA22923A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86211292A 1992-04-02 1992-04-02
US96876092A 1992-10-30 1992-10-30
PCT/US1993/001988 WO1993019747A1 (fr) 1992-04-02 1993-03-05 Composes destines a traiter les maladies allergiques et inflammatoires

Publications (1)

Publication Number Publication Date
MA22923A1 true MA22923A1 (fr) 1994-04-01

Family

ID=27127669

Family Applications (1)

Application Number Title Priority Date Filing Date
MA23149A MA22923A1 (fr) 1992-04-02 1993-04-01 Procede de preparation de nouveaux composes .

Country Status (10)

Country Link
US (1) US5602173A (fr)
EP (1) EP0634930A4 (fr)
JP (1) JP3195352B2 (fr)
CN (1) CN1094711A (fr)
AU (1) AU3738293A (fr)
IL (1) IL105223A0 (fr)
MA (1) MA22923A1 (fr)
MX (1) MX9301903A (fr)
SI (1) SI9300170A (fr)
WO (1) WO1993019747A1 (fr)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0919544T3 (da) * 1992-04-02 2003-09-15 Smithkline Beecham Corp Forbindelser egnede til behandling af allergiske og inflammatoriske sygdomme
GB9312853D0 (en) 1993-06-22 1993-08-04 Euro Celtique Sa Chemical compounds
US5646156A (en) * 1994-04-25 1997-07-08 Merck & Co., Inc. Inhibition of eosinophil activation through A3 adenosine receptor antagonism
US5591776A (en) 1994-06-24 1997-01-07 Euro-Celtique, S.A. Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV
US5922751A (en) 1994-06-24 1999-07-13 Euro-Celtique, S.A. Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
US5578576A (en) * 1994-09-02 1996-11-26 Dalhousie University Method and composition for treating intestinal wounds or ulcers
CA2206287C (fr) * 1994-12-13 2001-03-20 Mark Chasin Aryle thioxanthines
JPH10511659A (ja) * 1994-12-23 1998-11-10 スミスクライン・ビーチャム・コーポレイション １，４，４−（三置換）シクロヘキサン単量体および関連する化合物
WO1996020160A1 (fr) * 1994-12-23 1996-07-04 Smithkline Beecham Corporation Dimeres 1,3,3-(trisubstitues)cyclohexane et composes apparentes
WO1996019979A1 (fr) * 1994-12-23 1996-07-04 Smithkline Beecham Corporation Dimeres de 1,4,4-(trisubstitue)cyclohexane et composes apparentes
DK0828728T3 (da) * 1995-05-18 2003-05-19 Altana Pharma Ag Phenyldihydrobenzofuraner
JPH11505539A (ja) * 1995-05-18 1999-05-21 ビイク グルデン ロンベルク ヒェーミッシェ ファブリーク ゲゼルシャフト ミット ベシュレンクテル ハフツング シクロヘキシルジヒドロベンゾフラン
US6268373B1 (en) 1995-06-07 2001-07-31 Euro-Celtique S.A. Trisubstituted thioxanthines
US6166041A (en) 1995-10-11 2000-12-26 Euro-Celtique, S.A. 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma
US5891883A (en) * 1995-12-21 1999-04-06 Smithkline Beecham Corporation 4,4-(disubstituted)cyclohexan-1-ols monomers and related compounds
US6075016A (en) 1996-04-10 2000-06-13 Euro-Celtique S.A. 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity
US5744473A (en) * 1996-09-16 1998-04-28 Euro-Celtique, S.A. PDE IV inhibitors: "bis-compounds"
EP1327627A1 (fr) * 1997-02-12 2003-07-16 SmithKline Beecham Corporation Composés et procédé de préparation d'acides 4-phényle-4-cyanocyclohéxanoiques substituées
EP1524268B1 (fr) * 1997-02-12 2007-01-17 Smithkline Beecham Corporation Composés et procédé de préparation d'acides 4-phényle-4-cyanocyclohexanoiques substitués
MY118813A (en) * 1997-02-12 2005-01-31 Smithkline Beecham Corp Compounds and method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids
UY26268A1 (es) * 1999-08-06 2001-01-31 Smithkline Beecham Corp Procedimiento para preparar acidos a traves de alfa-cloroep xi- esteres ley 17164 art 127
US20040220424A1 (en) * 1999-08-06 2004-11-04 Smithkline Beecham Corporation Process for preparing acids via alpha-chloroepoxy esters
EP1671651B1 (fr) 1999-08-21 2009-11-11 Nycomed GmbH Combinaison synergique de pumafentrine et salméterol
US6555572B2 (en) * 2000-03-16 2003-04-29 Inflazyme Pharmaceuticals Ltd. Benzylated PDE4 inhibitors
CZ301834B6 (cs) 2000-08-11 2010-07-07 Ono Pharmaceutical Co., Ltd. Piperidinové deriváty a cinidlo, které tyto deriváty obsahuje jako úcinnou prísadu
EP1481969B1 (fr) * 2002-02-08 2011-01-19 Ono Pharmaceutical Co., Ltd. Composes derives de piperidine et medicaments contenant ces composes en tant que principe actif
TW200302724A (en) * 2002-02-08 2003-08-16 Ono Pharmaceutical Co Piperiding derivative compound and pharmaceuticals containing same as active ingredient
WO2004016596A1 (fr) * 2002-08-19 2004-02-26 Glenmark Pharmaceuticals Limited Composes condenses heterocycliques utilises comme inhibiteurs de pde-iv dans le traitement de troubles inflammatoires et allergiques
ATE380185T1 (de) 2002-10-23 2007-12-15 Glenmark Pharmaceuticals Ltd Tricyclische verbindungen zur behandlung von entzündlichen- und allergischen erkrankungen: verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
WO2004087211A2 (fr) 2003-04-01 2004-10-14 Applied Research Systems Ars Holding N.V. Inhibiteurs de phosphodiesterases dans l'infecondite
KR20060017494A (ko) 2003-04-11 2006-02-23 그렌마크 파머수티칼스 에스. 아. 염증 및 알레르기성 질환 치료용으로 유용한 신규 헤테로사이클릭 화합물, 이의 제조방법 및 이를 함유하는 약학 조성물
US20050026883A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a PDE-4 inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20090274676A1 (en) * 2003-07-31 2009-11-05 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a pde-4 inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20050085430A1 (en) * 2003-07-31 2005-04-21 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a PDE-4 inhibitor for treatment of asthma or chronic obstructive pulmonary disease
JP2009519206A (ja) 2004-10-13 2009-05-14 グレンマーク・ファーマシューティカルズ・エスエー Ｎ−（３，５−ジクロロピリジン−４−イル）−４−ジフルオロメトキシ−８−メタンスルホンアミド−ジベンゾ［ｂ，ｄ］フラン−１−カルボキサミドの製造法
SI1831227T1 (sl) 2004-12-17 2013-09-30 Glenmark Pharmaceuticals S.A. Nove heterociklične spojine uporabne za zdravljenje vnetnih in alergijskih motenj
EP1831227B1 (fr) 2004-12-17 2013-06-19 Glenmark Pharmaceuticals S.A. Nouveaux composes heterocycliques utiles pour le traitement de troubles inflammatoires et allergiques
CA2688161C (fr) 2007-06-04 2020-10-20 Kunwar Shailubhai Agonistes de guanylase cyclase utiles pour le traitement de troubles gastro-intestinaux, d'inflammation, de cancer et d'autres troubles
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP2328910B1 (fr) 2008-06-04 2014-08-06 Synergy Pharmaceuticals Inc. Agonistes de guanylate cyclase utile dans le traitement de troubles gastro-intestinaux, d'une inflammation, d'un cancer et d'autres troubles
EP3241839B1 (fr) 2008-07-16 2019-09-04 Bausch Health Ireland Limited Agonistes de guanylate cyclase utiles pour le traitement de troubles gastro-intestinaux, inflammatoires, cancéreux et autres
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
DK2681236T3 (en) 2011-03-01 2018-04-16 Synergy Pharmaceuticals Inc PROCEDURE FOR MANUFACTURING GUANYLATE CYCLASE-C-AGONISTS
CA2902348C (fr) 2013-02-25 2021-11-30 Synergy Pharmaceuticals Inc. Agonistes de la guanylate cyclase et applications associees
HK1220611A1 (zh) 2013-03-15 2017-05-12 Bausch Health Ireland Limited 用於治疗胃肠道病症的组成物
WO2014151206A1 (fr) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonistes de la guanylate cyclase et leurs utilisations
CN113388007A (zh) 2013-06-05 2021-09-14 博士医疗爱尔兰有限公司 鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法
BR112016002789A2 (pt) 2013-08-09 2017-11-21 Ardelyx Inc compostos e métodos para inibir transporte de fosfato
WO2020237096A1 (fr) 2019-05-21 2020-11-26 Ardelyx, Inc. Combinaison pour baisser le phosphate sérique chez un patient

Also Published As

Publication number Publication date
WO1993019747A1 (fr) 1993-10-14
IL105223A0 (en) 1994-08-26
MX9301903A (es) 1994-08-31
CN1094711A (zh) 1994-11-09
US5602173A (en) 1997-02-11
EP0634930A4 (en) 1995-02-22
EP0634930A1 (fr) 1995-01-25
JPH07508261A (ja) 1995-09-14
AU3738293A (en) 1993-11-08
JP3195352B2 (ja) 2001-08-06
SI9300170A (sl) 1993-12-31

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