[go: up one dir, main page]

Turner et al., 2002 - Google Patents

Specificity of memapsin 1 and its implications on the design of memapsin 2 (β-secretase) inhibitor selectivity

Turner et al., 2002

View PDF
Document ID
3264412906170615118
Author
Turner R
Loy J
Nguyen C
Devasamudram T
Ghosh A
Koelsch G
Tang J
Publication year
Publication venue
Biochemistry

External Links

Snippet

Memapsin 1 is closely homologous to memapsin 2 (BACE), or β-secretase, whose action on β-amyloid precursor protein (APP) leads to the production of β-amyloid (Aβ) peptide and the progression of Alzheimer's disease. Memapsin 2 is a current target for the development of …
Continue reading at www.academia.edu (PDF) (other versions)

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing

Similar Documents

Publication Publication Date Title
Turner et al. Specificity of memapsin 1 and its implications on the design of memapsin 2 (β-secretase) inhibitor selectivity
Turner et al. Subsite specificity of memapsin 2 (β-secretase): implications for inhibitor design
Altalhi et al. PAI-1 in diabetes: pathophysiology and role as a therapeutic target
Mitsudo et al. Inhibition of serine proteinases plasmin, trypsin, subtilisin A, cathepsin G, and elastase by LEKTI: a kinetic analysis
Pallares et al. Structure of human carboxypeptidase A4 with its endogenous protein inhibitor, latexin
Paul et al. Natural Catalytic Antibodies: Peptide-hydrolyzing Activities of Bence Jones Proteins and VL Fragment (∗)
Labat-de-Hoz et al. Formins in human disease
Wen et al. The plasma and cytoplasmic forms of human gelsolin differ in disulfide structure
Van den Steen et al. Generation of glycosylated remnant epitopes from human collagen type II by gelatinase B
Luque et al. Molecular basis of resistance to HIV-1 protease inhibition: a plausible hypothesis
Kurochkin et al. Toward allosterically increased catalytic activity of insulin-degrading enzyme against amyloid peptides
Kong et al. Copper binding to the Alzheimer’s disease amyloid precursor protein
Yuan et al. A selective activity-based probe for the papain family cysteine protease dipeptidyl peptidase I/cathepsin C
Ghosh et al. Design, synthesis and X-ray structure of protein− ligand complexes: Important insight into selectivity of memapsin 2 (β-Secretase) inhibitors
Oliveira et al. Isomannide-based peptidomimetics as inhibitors for human tissue kallikreins 5 and 7
García Díaz et al. Ca2+ dependency of calpain 3 (p94) activation
Jia et al. Mutations in calpain 3 associated with limb girdle muscular dystrophy: analysis by molecular modeling and by mutation in m-calpain
Kallergi et al. Targeting and maturation of Erv1/ALR in the mitochondrial intermembrane space
Hruz et al. Cysteine-scanning mutagenesis of transmembrane segment 11 of the GLUT1 facilitative glucose transporter
Wlodawer et al. Inhibitor complexes of the Pseudomonas serine-carboxyl proteinase
McGrath et al. Crystal structure of phenylmethanesulfonyl fluoride-treated human chymase at 1.9 Å
Kornacker et al. An inhibitor binding pocket distinct from the catalytic active site on human β-APP cleaving enzyme
Pop et al. Mutations in the procaspase-3 dimer interface affect the activity of the zymogen
Radisky et al. Binding, proteolytic, and crystallographic analyses of mutations at the protease− inhibitor interface of the subtilisin BPN ‘/chymotrypsin inhibitor 2 complex
Stanley et al. Amino acids responsible for reduced affinities of vitamin K-dependent propeptides for the carboxylase