[go: up one dir, main page]

Gorske et al., 2006 - Google Patents

Interception of quorum sensing in Staphylococcus aureus: a new niche for peptidomimetics

Gorske et al., 2006

Document ID
18302685759292761567
Author
Gorske B
Blackwell H
Publication year
Publication venue
Organic & Biomolecular Chemistry

External Links

Snippet

Pathogenesis in Staphylococcus aureus is dependent on local cell density and is regulated in part by small macrocyclic peptides. Natural and artificial peptide inhibitors of this quorum sensing response have been synthesized and evaluated in structure–activity relationship …
Continue reading at pubs.rsc.org (other versions)

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries

Similar Documents

Publication Publication Date Title
Yang et al. Ribosomally synthesized and post‐translationally modified peptide natural products: New insights into the role of leader and core peptides during biosynthesis
Gorske et al. Interception of quorum sensing in Staphylococcus aureus: a new niche for peptidomimetics
Mahanta et al. Biosynthesis and chemical applications of thioamides
Lyon et al. Key determinants of receptor activation in the agr autoinducing peptides of Staphylococcus aureus
Lyon et al. Peptide signaling in Staphylococcus aureus and other Gram-positive bacteria
Kopp et al. Macrocyclization strategies in polyketide and nonribosomal peptide biosynthesis
Tseng et al. Characterization of the surfactin synthetase C-terminal thioesterase domain as a cyclic depsipeptide synthase
Williams et al. The vancomycin group of antibiotics and the fight against resistant bacteria
Chatterjee et al. Biosynthesis and mode of action of lantibiotics
Knerr et al. Discovery, biosynthesis, and engineering of lantipeptides
EP2320927B1 (en) Modified peptides as potent inhibitors of the psd-95/nmda receptor interaction
Tal-Gan et al. Characterization of structural elements in native autoinducing peptides and non-native analogues that permit the differential modulation of AgrC-type quorum sensing receptors in Staphylococcus aureus
Paul et al. Mutants of the zinc ligands of lacticin 481 synthetase retain dehydration activity but have impaired cyclization activity
Levengood et al. Investigation of the substrate specificity of lacticin 481 synthetase by using nonproteinogenic amino acids
US20160326217A1 (en) Methods and Compositions Related to Cyclic Peptide Synthesis
Philmus et al. Substrate specificity and scope of MvdD, a GRASP-like ligase from the microviridin biosynthetic gene cluster
Polaske et al. Chemical and biomolecular insights into the Staphylococcus aureus agr quorum sensing system: Current progress and ongoing challenges
Deane et al. In vitro biosynthesis and substrate tolerance of the plantazolicin family of natural products
Bionda et al. Effect of Ester to Amide or N‐Methylamide Substitution on Bacterial Membrane Depolarization and Antibacterial Activity of Novel Cyclic Lipopeptides
Ohsawa et al. Total synthesis and structural revision of cyclotetrapeptide asperterrestide A
Hintzen et al. The Complete Assessment of Small Molecule and Peptidomimetic Inhibitors of Sortase A Towards Antivirulence Treatment
CA2761471C (en) Biologically produced cyclic affinity tags.
Barrett et al. Thioamide-containing peptides and proteins
Roblin et al. Antimicrobial Ribosomally synthesized and post-translationally modified peptides as a source of alternatives to antibiotics: a focus on the Sactipeptides and Ranthipeptides subclasses
Kapoerchan et al. Gramicidin S Derivatives Containing cis‐and trans‐Morpholine Amino Acids (MAAs) as Turn Mimetics