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Miyauchi et al., 1994 - Google Patents

Oral Administration of BOF‐A2 to Rats with Lung Transplanted Tumors Results in Increased 5‐Fluorouracil Levels

Miyauchi et al., 1994

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Document ID
18134694293030112158
Author
Miyauchi S
Imaoka T
Utsunomiya T
Hayashi K
Kubo M
Kawaguchi T
Matsui Y
Publication year
Publication venue
Japanese journal of cancer research

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Snippet

A new tumor model was developed in which solid Yoshida sarcoma tissue injected intravenously developed into tumors in the lungs of about 30%(13/42) of the inoculated rats. Histological examination revealed that alveoli were occupied with tumor cells and the …
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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