Wang et al., 2023 - Google Patents
Inhibition of lysosome-tethered Ragulator-Rag-3D complex restricts the replication of Enterovirus 71 and Coxsackie A16Wang et al., 2023
View HTML- Document ID
- 16768771512038349558
- Author
- Wang X
- Hu Z
- Zhang W
- Wu S
- Hao Y
- Xiao X
- Li J
- Yu X
- Yang C
- Wang J
- Zhang H
- Ma F
- Shi W
- Wang J
- Lei X
- Zhang X
- He S
- Publication year
- Publication venue
- Journal of Cell Biology
External Links
Snippet
Enterovirus 71 (EV71) and Coxsackie A16 (CVA16) are two major causative agents of hand, foot, and mouth disease (HFMD) in young children. However, the mechanisms regulating the replication and pathogenesis of EV71/CVA16 remain incompletely understood. We …
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriphage
- C12Q1/701—Specific hybridization probes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
- G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Meng et al. | SARS-CoV-2 Omicron spike mediated immune escape and tropism shift | |
| Zhao et al. | Novel cleavage sites identified in SARS-CoV-2 spike protein reveal mechanism for cathepsin L-facilitated viral infection and treatment strategies | |
| Cheng et al. | Virus-induced p38 MAPK activation facilitates viral infection | |
| Gupta | SARS-CoV-2 Omicron spike mediated immune escape and tropism shift | |
| Arita et al. | Valosin-containing protein (VCP/p97) is required for poliovirus replication and is involved in cellular protein secretion pathway in poliovirus infection | |
| Wang et al. | Inhibition of lysosome-tethered Ragulator-Rag-3D complex restricts the replication of Enterovirus 71 and Coxsackie A16 | |
| Karim et al. | Numb-associated kinases are required for SARS-CoV-2 infection and are cellular targets for antiviral strategies | |
| Liu et al. | The ESCRT-I subunit Tsg101 plays novel dual roles in entry and replication of classical swine fever virus | |
| He et al. | Bovine lactoferrin inhibits SARS‐CoV‐2 and SARS‐CoV‐1 by targeting the RdRp complex and alleviates viral infection in the hamster model | |
| Li et al. | HSC70 inhibits spring viremia of carp virus replication by inducing MARCH8-mediated lysosomal degradation of G protein | |
| Zhang et al. | Enterovirus D68 infection induces TDP-43 cleavage, aggregation, and neurotoxicity | |
| Yang et al. | Asialoglycoprotein receptor 1 promotes SARS-CoV-2 infection of human normal hepatocytes | |
| Banerjee et al. | Comprehensive role of SARS‐CoV‐2 spike glycoprotein in regulating host signaling pathway | |
| Tang et al. | Heat shock protein 60 is involved in viral replication complex formation and facilitates foot and mouth virus replication by stabilizing viral nonstructural proteins 3A and 2C | |
| Nam et al. | Radicicol inhibits chikungunya virus replication by targeting nonstructural protein 2 | |
| Chen et al. | Phenanthridine derivative host heat shock cognate 70 down-regulators as porcine epidemic diarrhea virus inhibitors | |
| Murer et al. | Chemical evolution of rhinovirus identifies capsid-destabilizing mutations driving low-pH-independent genome uncoating | |
| Zhao et al. | N-acetyltransferase 8 promotes viral replication by increasing the stability of enterovirus 71 nonstructural proteins | |
| Salgado-Benvindo et al. | Characterization of SARS-CoV-2 replication in human H1299/ACE2 cells: a versatile and practical infection model for antiviral research and beyond | |
| Shaw et al. | Rationally derived inhibitors of hepatitis C virus (HCV) p7 channel activity reveal prospect for bimodal antiviral therapy | |
| Zhou et al. | TRIM6 facilitates SARS‐CoV‐2 proliferation by catalyzing the K29‐typed ubiquitination of NP to enhance the ability to bind viral genomes | |
| Yan et al. | Involvement of VCP/UFD1/Nucleolin in the viral entry of Enterovirus A species | |
| Loi et al. | Decoy peptides effectively inhibit the binding of SARS-CoV-2 to ACE2 on oral epithelial cells | |
| Lee et al. | Distinct molecular mechanisms characterizing pathogenesis of SARS-CoV-2 | |
| CN105535975B (en) | Application of the vesicle-associated membrane albumen 1 in prevention enterovirns type 71 infection |