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Schmidt et al., 2006 - Google Patents

Directed evolution of an esterase from Pseudomonas fluorescens yields a mutant with excellent enantioselectivity and activity for the kinetic resolution of a chiral …

Schmidt et al., 2006

Document ID
15761303721706564375
Author
Schmidt M
Hasenpusch D
Kähler M
Kirchner U
Wiggenhorn K
Langel W
Bornscheuer U
Publication year
Publication venue
ChemBioChem

External Links

Snippet

A triple mutant of an esterase from Pseudomonas fluorescens (PFE) that was created by directed evolution exhibited high enantioselectivity (E= 89) in a kinetic resolution and yielded the building block (S)‐but‐3‐yn‐2‐ol. Surprisingly, a mutation close to the active site …
Continue reading at chemistry-europe.onlinelibrary.wiley.com (other versions)

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