[go: up one dir, main page]

Superti‐Furga et al., 1988 - Google Patents

The− 117 mutation in Greek HPFH affects the binding of three nuclear factors to the CCAAT region of the gamma‐globin gene.

Superti‐Furga et al., 1988

View PDF
Document ID
1559952833057144639
Author
Superti‐Furga G
Barberis A
Schaffner G
Busslinger M
Publication year
Publication venue
The EMBO journal

External Links

Snippet

The Greek form of hereditary persistence of fetal hemoglobin (HPFH) is associated with a point mutation immediately upstream of the distal of the two CCAAT elements of the A gamma‐globin gene. Three proteins present in nuclear extracts of erythroleukemia cells …
Continue reading at link.springer.com (PDF) (other versions)

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects

Similar Documents

Publication Publication Date Title
Superti‐Furga et al. The− 117 mutation in Greek HPFH affects the binding of three nuclear factors to the CCAAT region of the gamma‐globin gene.
Gumucio et al. Nuclear Proteins That Bind the Human ϒ-Globin Gene Promoter: Alterations in Binding Produced by Point Mutations Associated with Hereditary Persistence of Fetal Hemoglobin
Böttinger et al. The human β2 integrin CD18 promoter consists of two inverted Ets cis elements
Moss et al. Systematic binding analysis of the insulin gene transcription control region: insulin and immunoglobulin enhancers utilize similar transactivators
Xiao et al. In vitro binding of several cell-specific and ubiquitous nuclear proteins to the GT-I motif of the SV40 enhancer.
Vaulont et al. Proteins binding to the liver-specific pyruvate kinase gene promoter: a unique combination of known factors
Kamachi et al. Purification of a mouse nuclear factor that binds to both the A and B cores of the polyomavirus enhancer
Inoue et al. IκBγ, a 70 kd protein identical to the C-terminal half of p110 NF-κB: a new member of the IκB family
Bourdon et al. Further characterisation of the p53 responsive element–identification of new candidate genes for trans-activation by p53
Kuo et al. A transcriptional hierarchy involved in mammalian cell-type specification
Cockell et al. Identification of a cell-specific DNA-binding activity that interacts with a transcriptional activator of genes expressed in the acinar pancreas
Hofmann et al. RAP-1 factor is necessary for DNA loop formation in vitro at the silent mating type locus HML
Liu et al. The retinoblastoma interacting zinc finger gene RIZ produces a PR domain-lacking product through an internal promoter
US6150090A (en) Nuclear factors associated with transcriptional regulation
Fucharoen et al. A novel CT transition within the distal CCAAT motif of the Gγ-globin gene in the Japanese HPFH: implication of factor binding in elevated fetal globin expression
Fischer et al. Interdependent transcription control elements regulate the expression of the SPRR2A gene during keratinocyte terminal differentiation
Coin et al. Phosphorylation of XPB helicase regulates TFIIH nucleotide excision repair activity
Jackson et al. Developmental modulation of protein binding to beta-globin gene regulatory sites within chicken erythrocyte nuclei.
Gopal-Srivastava et al. The murine αB-crystallin/small heat shock protein enhancer: identification of αBE-1, αBE-2, αBE-3, and MRF control elements
Shimizu et al. Both muscle-specific and ubiquitous nuclear factors are required for muscle-specific expression of the myosin heavy-chain β gene in cultured cells
Manley et al. Two factors that bind to highly conserved sequences in mammalian type C retroviral enhancers
US5215909A (en) Human cholinesterase genes
Pittoggi et al. Specific localization of transcription factors in the chromatin of mouse mature spermatozoa
Ganter et al. Transcriptional activation by the myb proteins requires a specific local promoter structure
Takemoto et al. The promoter of the endo A cytokeratin gene is activated by a 3′ downstream enhancer