Pajon et al., 2010 - Google Patents
Frequency of factor H-binding protein modular groups and susceptibility to cross-reactive bactericidal activity in invasive meningococcal isolatesPajon et al., 2010
View PDF- Document ID
- 1521363680226497351
- Author
- Pajon R
- Beernink P
- Harrison L
- Granoff D
- Publication year
- Publication venue
- Vaccine
External Links
Snippet
Meningococcal factor H-binding protein (fHbp) is a promising vaccine candidate that elicits serum bactericidal antibodies in humans. Based on sequence variability of the entire protein, fHbp has been divided into three variant groups or two sub-families. We recently …
- 230000000844 anti-bacterial 0 title abstract description 37
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
- G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay
- G01N33/569—Immunoassay; Biospecific binding assay for micro-organisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
- G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Hybridisation probes
- C12Q1/6888—Hybridisation probes for detection or identification of organisms
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING; COUNTING
- G06F—ELECTRICAL DIGITAL DATA PROCESSING
- G06F19/00—Digital computing or data processing equipment or methods, specially adapted for specific applications
- G06F19/10—Bioinformatics, i.e. methods or systems for genetic or protein-related data processing in computational molecular biology
- G06F19/22—Bioinformatics, i.e. methods or systems for genetic or protein-related data processing in computational molecular biology for sequence comparison involving nucleotides or amino acids, e.g. homology search, motif or SNP [Single-Nucleotide Polymorphism] discovery or sequence alignment
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING; COUNTING
- G06F—ELECTRICAL DIGITAL DATA PROCESSING
- G06F19/00—Digital computing or data processing equipment or methods, specially adapted for specific applications
- G06F19/10—Bioinformatics, i.e. methods or systems for genetic or protein-related data processing in computational molecular biology
- G06F19/18—Bioinformatics, i.e. methods or systems for genetic or protein-related data processing in computational molecular biology for functional genomics or proteomics, e.g. genotype-phenotype associations, linkage disequilibrium, population genetics, binding site identification, mutagenesis, genotyping or genome annotation, protein-protein interactions or protein-nucleic acid interactions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Pajon et al. | Frequency of factor H-binding protein modular groups and susceptibility to cross-reactive bactericidal activity in invasive meningococcal isolates | |
| Del Tordello et al. | Reverse vaccinology: exploiting genomes for vaccine design | |
| Jolley et al. | Molecular typing of meningococci: recommendations for target choice and nomenclature | |
| Mongodin et al. | Inter-and intra-specific pan-genomes of Borrelia burgdorferi sensu lato: genome stability and adaptive radiation | |
| Stentzel et al. | Specific serum IgG at diagnosis of Staphylococcus aureus bloodstream invasion is correlated with disease progression | |
| Beernink et al. | The modular architecture of meningococcal factor H-binding protein | |
| Brehony et al. | Variation of the factor H-binding protein of Neisseria meningitidis | |
| Vu et al. | Cooperative serum bactericidal activity between human antibodies to meningococcal factor H binding protein and neisserial heparin binding antigen | |
| Kelly et al. | Reverse vaccinology and vaccines for serogroup B Neisseria meningitidis | |
| Hadad et al. | Novel meningococcal 4 CM enB vaccine antigens–prevalence and polymorphisms of the encoding genes in Neisseria gonorrhoeae | |
| Smeesters et al. | Differences among group A streptococcus epidemiological landscapes: consequences for M protein-based vaccines? | |
| Sette et al. | Immune epitope mapping in the post-genomic era: lessons for vaccine development | |
| Rodrigues et al. | Genomic surveillance of 4CMenB vaccine antigenic variants among disease-causing Neisseria meningitidis isolates, United Kingdom, 2010–2016 | |
| Jacobsson et al. | Sequence constancies and variations in genes encoding three new meningococcal vaccine candidate antigens | |
| Pérez-Losada et al. | Population genetics of Neisseria gonorrhoeae in a high-prevalence community using a hypervariable outer membrane porB and 13 slowly evolving housekeeping genes | |
| Freudenburg-de Graaf et al. | Predicted coverage by 4CMenB vaccine against invasive meningococcal disease cases in the Netherlands | |
| Bettinger et al. | Controlling serogroup B invasive meningococcal disease: the Canadian perspective | |
| Harris et al. | Preclinical evidence for the potential of a bivalent fHBP vaccine to prevent Neisseria meningitidis serogroup C disease | |
| Waśko et al. | Genetic variability of Polish serogroup B meningococci (2010–2016) including the 4CMenB vaccine component genes | |
| Fazio et al. | Cross-reactivity of 4CMenB vaccine-induced antibodies against meningococci belonging to non-B serogroups in Italy | |
| Balmer et al. | Meningococcal disease: how to prevent and how to manage | |
| Goeders et al. | Molecular and WGS-based characterization of invasive Neisseria meningitidis isolates collected in Belgium (2016–2022) and MenB-FHbp vaccine coverage estimation of serogroup B | |
| Lucidarme et al. | Genetic distribution of noncapsular meningococcal group B vaccine antigens in Neisseria lactamica | |
| Tzanakaki et al. | Estimated strain coverage of serogroup B meningococcal vaccines: a retrospective study for disease and carrier strains in Greece (2010–2017) | |
| Chang et al. | Distribution of Neisseria meningitidis serogroup B (NmB) vaccine antigens in meningococcal disease causing isolates in the United States during 2009–2014, prior to NmB vaccine licensure |