Lavie et al., 1990 - Google Patents
Activation of phospholipase D by sphingoid bases in NG108-15 neural-derived cells.Lavie et al., 1990
View PDF- Document ID
- 13019091825936222898
- Author
- Lavie Y
- Liscovitch M
- Publication year
- Publication venue
- Journal of Biological Chemistry
External Links
Snippet
Recent studies suggest that signal-dependent formation of phosphatidic acid by phospholipase D-catalyzed hydrolysis of phosphatidylcholine is a novel trans-membrane signaling pathway in mammalian cells. We here demonstrate that sphingosine, as well as …
- 102000011420 Phospholipase D 0 title abstract description 68
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
- G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
- G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P-C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Lavie et al. | Activation of phospholipase D by sphingoid bases in NG108-15 neural-derived cells. | |
| Desai et al. | Signaling pathways for sphingosylphosphorylcholine-mediated mitogenesis in Swiss 3T3 fibroblasts. | |
| Lavie et al. | Inhibition of phosphatidic acid phosphohydrolase activity by sphingosine: Dual action of sphingosine in diacylglycerol signal termination | |
| Hannun et al. | Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets. | |
| US5830916A (en) | Inhibitor of ceramidase | |
| Wilson et al. | Modulation of the free sphingosine levels in human neutrophils by phorbol esters and other factors. | |
| Okazaki et al. | Role of ceramide as a lipid mediator of 1 alpha, 25-dihydroxyvitamin D3-induced HL-60 cell differentiation. | |
| Zelenka | Lens lipids | |
| US4937232A (en) | Inhibition of protein kinase C by long-chain bases | |
| Fu et al. | Nuclear lipid mediators: Role of nuclear sphingolipids and sphingosine‐1‐phosphate signaling in epigenetic regulation of inflammation and gene expression | |
| Betts et al. | Dissociation of endogenous cellular ceramide from NF-kappa B activation. | |
| Zaleska et al. | Lipid hydroperoxides inhibit reacylation of phospholipids in neuronal membranes | |
| WO1988001869A1 (en) | Inhibition of protein kinase c by long-chain bases | |
| Hansen et al. | Formation ofN‐acyl‐phosphatidylethanolamine andN‐acylethanolamine (including anandamide) during glutamate‐induced neurotoxicity | |
| Gustavsson et al. | Stimulation of phospholipase D activity by phorbol esters in cultured astrocytes | |
| Cao et al. | Regulation by vitamin E of phosphatidylcholine metabolism in rat heart | |
| Ghidoni et al. | Use of sphingolipid analogs: benefits and risks | |
| Mikami et al. | Structure-dependent absorption of atypical sphingoid long-chain bases from digestive tract into lymph | |
| Yamazaki et al. | Phorbol 12-myristate 13-acetate inhibits binding of leukotriene B4 and platelet-activating factor and the responses they induce in neutrophils: site of action. | |
| Chauvelot et al. | Prostaglandins and enzyme secretion from dispersed rat pancreatic acinar cells | |
| HUT65932A (en) | Methods for inducing cell differentiation using ceramides | |
| Fischbeck et al. | Analysis of sphingomyelin in meat based on hydrophilic interaction liquid chromatography coupled to electrospray ionization− tandem mass spectrometry (HILIC-HPLC-ESI-MS/MS) | |
| Dudeja et al. | Dexamethasone influences the lipid fluidity, lipid composition and glycosphingolipid glycosyltransferase activities of rat proximal-small-intestinal Golgi membranes | |
| Williams et al. | Inhibition of serine palmitoyltransferase activity in rabbit aorta by L-cycloserine. | |
| EP0944309A1 (en) | Compositions for modulating intracellular inositol trisphosphate concentration and uses thereof |