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Saccu, 2025 - Google Patents

In vitro characterization of 3D culture-based differentiation of human liver stem cells

Saccu, 2025

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Document ID
12806471064708365115
Author
Saccu G
Publication year

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A shortage of functional hepatocytes hampers drug safety testing and therapeutic applications because mature hepatocytes cannot be expanded and tend to lose functionality in vitro. Previous studies indicated that human liver stem cells (HLSCs) can differentiate into …
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues ; Not used, see subgroups
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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