[go: up one dir, main page]

Leonidas et al., 2002 - Google Patents

Crystallographic studies on the role of the C-terminal segment of human angiogenin in defining enzymatic potency

Leonidas et al., 2002

Document ID
10894512961925861737
Author
Leonidas D
Shapiro R
Subbarao G
Russo A
Acharya K
Publication year
Publication venue
Biochemistry

External Links

Snippet

Human angiogenin (Ang) is an RNase in the pancreatic RNase superfamily that induces angiogenesis. Its catalytic activity is comparatively weak, but nonetheless critical for biological activity. The crystal structure of Ang has shown that enzymatic potency is …
Continue reading at pubs.acs.org (other versions)

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING; COUNTING
    • G06F—ELECTRICAL DIGITAL DATA PROCESSING
    • G06F19/00—Digital computing or data processing equipment or methods, specially adapted for specific applications
    • G06F19/10—Bioinformatics, i.e. methods or systems for genetic or protein-related data processing in computational molecular biology
    • G06F19/16—Bioinformatics, i.e. methods or systems for genetic or protein-related data processing in computational molecular biology for molecular structure, e.g. structure alignment, structural or functional relations, protein folding, domain topologies, drug targeting using structure data, involving two-dimensional or three-dimensional structures

Similar Documents

Publication Publication Date Title
Birrane et al. Structure of the lipoprotein lipase–GPIHBP1 complex that mediates plasma triglyceride hydrolysis
Turner et al. Structural locations and functional roles of new subsites S5, S6, and S7 in memapsin 2 (β-secretase)
Das et al. Structural basis for conformational plasticity of the Parkinson's disease-associated ubiquitin hydrolase UCH-L1
Yang et al. Crystal structure of a human aminoacyl-tRNA synthetase cytokine
Knoechel et al. Regulatory roles of the N-terminal domain based on crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands
Leonidas et al. Crystal Structures of Ribonuclease A Complexes with 5 ‘-Diphosphoadenosine 3 ‘-Phosphate and 5 ‘-Diphosphoadenosine 2 ‘-Phosphate at 1.7 Å Resolution
Son et al. Structure of human monoamine oxidase A at 2.2-Å resolution: the control of opening the entry for substrates/inhibitors
Vogl et al. Thermodynamic stability of annexin V E17G: equilibrium parameters from an irreversible unfolding reaction
Watson et al. Structure of HDAC3 bound to co-repressor and inositol tetraphosphate
Coleman et al. Crystal structures of the G protein Giα1 complexed with GDP and Mg2+: a crystallographic titration experiment
Sauer et al. Differential oligomerization of the deubiquitinases USP25 and USP28 regulates their activities
Lehmann et al. Structure of the Escherichia coli ThiS− ThiF complex, a key component of the sulfur transfer system in thiamin biosynthesis
Brown et al. Rational design of femtomolar inhibitors of isoleucyl tRNA synthetase from a binding model for pseudomonic acid-A
Raw et al. Structural and Biochemical Characterization of the GTPγS-, GDP⊙ Pi-, and GDP-Bound Forms of a GTPase-Deficient Gly42→ Val Mutant of Giα1
Bystrom et al. Crystal structures of Escherichia coli glycerol kinase variant S58→ W in complex with nonhydrolyzable ATP analogues reveal a putative active conformation of the enzyme as a result of domain motion
Colby et al. Active Site Modifications in a Double Mutant of Liver Alcohol Dehydrogenase: Structural Studies of Two Enzyme− Ligand Complexes
Sotelo-Mundo et al. Crystal structures of rat thymidylate synthase inhibited by Tomudex, a potent anticancer drug
Zhang et al. Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5, 10-dideazaacyclic-5, 6, 7, 8-tetrahydrofolic acid
Kim et al. Structure and hydride transfer mechanism of a moderate thermophilic dihydrofolate reductase from Bacillus stearothermophilus and comparison to its mesophilic and hyperthermophilic homologues
Fedorov et al. Ionic interactions in crystalline bovine pancreatic ribonuclease A
Lee et al. Crystal structures of Escherichia coli dihydrofolate reductase complexed with 5-formyltetrahydrofolate (folinic acid) in two space groups: evidence for enolization of pteridine O4
Leonidas et al. Toward rational design of ribonuclease inhibitors: High-resolution crystal structure of a ribonuclease A complex with a potent 3 ‘, 5 ‘-pyrophosphate-linked dinucleotide inhibitor
NO342699B1 (en) A bacterial ATP synthase binding domain.
Leonidas et al. Crystallographic studies on the role of the C-terminal segment of human angiogenin in defining enzymatic potency
Riccio et al. Structural insight and characterization of human Twinkle helicase in mitochondrial disease