[go: up one dir, main page]

Eldor et al., 1987 - Google Patents

Role of heparanase in platelet and tumor cell interactions with the subendothelial extracellular matrix

Eldor et al., 1987

Document ID
10064869627057922687
Author
Eldor A
Bar-Ner M
Yahalom J
Fuks Z
Vlodavsky I
Publication year
Publication venue
Seminars in thrombosis and hemostasis

External Links

Snippet

MATERIALS AND METHODS Fibroblast growth factor (FGF) was purified from bovine brain as described. 31 Dulbecco's modi fied Eagle's medium (DMEM, low glucose), Roswell Park Memorial Institute medium 1640,(RPMI-1640), calf serum, fetal calf serum, penicillin, and …
Continue reading at www.thieme-connect.com (other versions)

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/44—Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6437—Coagulation factor VIIa (3.4.21.21)

Similar Documents

Publication Publication Date Title
Bar-Ner et al. Inhibition of heparanase-mediated degradation of extracellular matrix heparan sulfate by non-anticoagulant heparin species
Yahalom et al. Degradation of sulfated proteoglycans in the subendothelial extracellular matrix by human platelet heparitinase.
EP0487627B1 (en) Wound healing preparations containing heparanase
US5262403A (en) Glycosaminoglycan derivatives and their use as inhibitors of tumor invasiveness of metastatic profusion-II
Bar‐Ner et al. Sequential degradation of heparan sulfate in the subendothelial extracellular matrix by highly metastatic lymphoma cells
Matzner et al. Degradation of heparan sulfate in the subendothelial extracellular matrix by a readily released heparanase from human neutrophils. Possible role in invasion through basement membranes.
Vlodavsky et al. Forty years of basic and translational heparanase research
Vlodavsky et al. Lymphoma cell-mediated degradation of sulfated proteoglycans in the subendothelial extracellular matrix: relationship to tumor cell metastasis
Marcum et al. Anticoagulantly active heparan sulfate proteoglycan and the vascular endothelium
Key et al. Vascular endothelial cell proteoglycans are susceptible to cleavage by neutrophils.
Wasteson et al. Effect of a platelet endoglycosidase on cell surface associated heparan sulphate of human cultured endothelial and glial cells
CA1316828C (en) Compounds having anti-metastatic and/or anti-inflammatory activity
US4945086A (en) Smooth muscle cell growth inhibitor
Eldor et al. Role of heparanase in platelet and tumor cell interactions with the subendothelial extracellular matrix
Peplow Glycosaminoglycan: a candidate to stimulate the repair of chronic wounds
Jin et al. Immunochemical localization of heparanase in mouse and human melanomas
CA2361612A1 (en) Peptides modulating activities of heparin, other glycosaminoglycans or proteoglycans
EP0669827B1 (en) Compositions for the regulation of cytokine activity
WO1988001280A1 (en) Glycosaminoglycan derivatives and their use as inhibitors of tumor invasiveness or metastatic profusion
Hatton et al. Evidence that rabbit 125I-antithrombin III binds to proteoheparan sulphate at the subendothelium of the rabbit aorta in vitro
Hatton et al. On the interaction of rabbit antithrombin III with the luminal surface of the normal and deendothelialized rabbit thoracic aorta in vitro
Yahalom et al. Platelet-tumor cell interaction with the subendothelial extracellular matrix: relationship to cancer metastasis
Keren et al. Inhibition of experimental metastasis and extracellular matrix degradation by butanol extracts from B16-F1 murine melanoma
Vlodavsky et al. Modulation of neovascularization and metastasis by species of heparin
Preissner Physiological role of vessel wall related antithrombotic mechanisms: contribution of endogenous and exogenous heparin-like components to the anticoagulant potential of the endothelium