[go: up one dir, main page]

Lecomte et al., 1999 - Google Patents

Chemical synthesis and structure–activity relationships of Ts κ, a novel scorpion toxin acting on apamin‐sensitive SK channel

Lecomte et al., 1999

View PDF
Document ID
8143885937363287182
Author
Lecomte C
Ferrat G
Fajloun Z
Van Rietschoten J
Rochat H
Martin‐Eauclaire M
Darbon H
Sabatier J
Publication year
Publication venue
The Journal of peptide research

External Links

Snippet

Tityus kappa (Ts κ), a novel toxin from the venom of the scorpion Tityus serrulatus, is a 35‐ residue polypeptide cross‐linked by three disulphide bridges and acts on small‐ conductance calcium‐activated potassium channels (SK channels). Ts κ was chemically …
Continue reading at www.academia.edu (PDF) (other versions)

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Similar Documents

Publication Publication Date Title
Minamino et al. Regional distribution of neuromedin K and neuromedin L in rat brain and spinal cord
Fajloun et al. Chemical synthesis and characterization of maurocalcine, a scorpion toxin that activates Ca2+ release channel/ryanodine receptors
LEBRUN et al. A four-disulphide-bridged toxin, with high affinity towards voltage-gated K+ channels, isolated from Heterometrus spinnifer (Scorpionidae) venom
Friederich et al. An actin-binding site containing a conserved motif of charged amino acid residues is essential for the morphogenic effect of villin
Martinez et al. . alpha.-Conotoxin EI, A New Nicotinic Acetylcholine Receptor Antagonist with Novel Selectivity
Sabatier et al. P05, a new leiurotoxin I-like scorpion toxin: Synthesis and structure-activity relationships of the. alpha.-amidated analog, a ligand of calcium-activated potassium channels with increased affinity
Faure et al. Multiplicity of acidic subunit isoforms of crotoxin, the phospholipase A2 neurotoxin from Crotalus durissus terrificus venom, results from posttranslational modifications
LÓPEZ‐OTÍN et al. The primary structure of the cytotoxin restrictocin
Romi et al. Synthesis and characterization of kaliotoxin. Is the 26-32 sequence essential for potassium channel recognition?
DE69730787T2 (en) Process for the preparation of PTH and PTrP analog compounds
Lecomte et al. Chemical synthesis and structure–activity relationships of Ts κ, a novel scorpion toxin acting on apamin‐sensitive SK channel
Zerrouk et al. Characterization of PO1, a new peptide ligand of the apamin‐sensitive Ca2+ activated K+ channel
EP1116727B1 (en) Peptide derivative
Sabatier et al. Leiurotoxin I, a scorpion toxin specific for Ca2+‐activated K+ channels Structure‐activity analysis using synthetic analogs
M'Barek et al. Synthesis and characterization of Pi4, a scorpion toxin from Pandinus imperator that acts on K+ channels
Benkhadir et al. Molecular cloning and functional expression of the alpha-scorpion toxin BotIII: pivotal role of the C-terminal region for its interaction with voltage-dependent sodium channels
CA2247328C (en) Neuropeptides originating in scorpion
Aird et al. Primary structure of γ-bungarotoxin, a new postsynaptic neurotoxin from venom of Bungarus multicinctus
Fajloun et al. Chemical synthesis and characterization of Pi1, a scorpion toxin from Pandinus imperator active on K+ channels
Laureto et al. Chemical synthesis and structural characterization of the RGD‐protein decorsin: A potent inhibitor of platelet aggregation
AU781608B2 (en) Buforin I as a specific inhibitor and therapeutic agent for botulinum toxin B and tetanus neurotoxins
Srairi‐Abid et al. Purification, characterization and molecular modelling of two toxin‐like proteins from the Androctonus australis Hector venom
Sabatier et al. Synthesis and Characterization of Leiurotoxin I Analogs Lacking One Disulfide Bridge: Evidence That Disulfide Pairing 3− 21 Is Not Required for Full Toxin Activity
Mansuelle et al. The amino acid sequence of toxin IV from the Androctonus australis scorpion: Differing effects of natural mutations in scorpion α‐toxins on their antigenic and toxic properties
Muller et al. Localization of two antigenic determinants in histone H4