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Ovadia et al., 2019 - Google Patents

Synthesis and anti-HCV activity of β-D-2′-deoxy-2′-α-chloro-2′-β-fluoro and β-d-2′-deoxy-2′-α-bromo-2′-β-fluoro nucleosides and their phosphoramidate …

Ovadia et al., 2019

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Document ID
7714418840215274851
Author
Ovadia R
Khalil A
Li H
De Schutter C
Mengshetti S
Zhou S
Bassit L
Coats S
Amblard F
Schinazi R
Publication year
Publication venue
Bioorganic & medicinal chemistry

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We report herein the synthesis and evaluation of a series of β-d-2′-deoxy-2′-α-chloro-2′- β-fluoro and β-d-2′-deoxy-2′-α-bromo-2′-β-fluoro nucleosides along with their corresponding phosphoramidate prodrugs. Key intermediates, lactols 11 and 12, were …
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    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
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    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or micotinamide-adenine dinucleotide
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