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Gao et al., 2022 - Google Patents

Synergistic anti-tumor effect of combining selective CDK7 and BRD4 inhibition in neuroblastoma

Gao et al., 2022

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Document ID
7345030365259157275
Author
Gao Y
Volegova M
Nasholm N
Das S
Kwiatkowski N
Abraham B
Zhang T
Gray N
Gustafson C
Krajewska M
George R
Publication year
Publication venue
Frontiers in Oncology

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Purpose Cyclin-dependent kinases (CDKs) that have critical roles in RNA polymerase II (Pol II)-mediated gene transcription are emerging as therapeutic targets in cancer. We have previously shown that THZ1, a covalent inhibitor of CDKs 7/12/13, leads to cytotoxicity in …
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