[go: up one dir, main page]

Botz et al., 2015 - Google Patents

Hydrophobic cyanine dye-doped micelles for optical in vivo imaging of plasma leakage and vascular disruption

Botz et al., 2015

View PDF
Document ID
6053978829306716300
Author
Botz B
Bölcskei K
Kemény
Sándor Z
Tékus V
Sétáló Jr G
Csepregi J
Mócsai A
Pintér E
Kollár L
Helyes Z
Publication year
Publication venue
Journal of biomedical optics

External Links

Snippet

Vascular leakage is an important feature of various disease conditions. In vivo optical imaging provides a great opportunity for the evaluation of this phenomenon. In the present study, we focus on the development and validation of a near-infrared (NIR) imaging formula …
Continue reading at www.spiedigitallibrary.org (PDF) (other versions)

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0054—Macromolecular compounds, i.e. oligomers, polymers, dendrimers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0076—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form dispersion, suspension, e.g. particles in a liquid, colloid, emulsion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
    • A61K47/48—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form

Similar Documents

Publication Publication Date Title
He et al. High affinity to skeleton rare earth doped nanoparticles for near-infrared II imaging
Marshall et al. Single-dose intravenous toxicity study of IRDye 800CW in Sprague-Dawley rats
Bhavane et al. NIR-II fluorescence imaging using indocyanine green nanoparticles
Li et al. Preoperative detection and intraoperative visualization of brain tumors for more precise surgery: A new dual‐modality MRI and NIR nanoprobe
Shi et al. Review on near-infrared heptamethine cyanine dyes as theranostic agents for tumor imaging, targeting, and photodynamic therapy
Wang et al. A nanoparticle-based strategy for the imaging of a broad range of tumours by nonlinear amplification of microenvironment signals
Ma et al. Cross‐link‐functionalized nanoparticles for rapid excretion in nanotheranostic applications
Chen et al. In vivo near-infrared fluorescence imaging of integrin αvβ3 in brain tumor xenografts
Hill et al. Near infrared fluorescent nanoparticles derived from hyaluronic acid improve tumor contrast for image-guided surgery
Harrison et al. Multimeric near IR–MR contrast agent for multimodal in vivo imaging
Wu et al. A novel photoacoustic nanoprobe of ICG@ PEG-Ag 2 S for atherosclerosis targeting and imaging in vivo
Zhang et al. Mitochondria‐targeting IR‐780 dye and its derivatives: synthesis, mechanisms of action, and theranostic applications
US20170314056A1 (en) Method of using near infrared fluorescent dyes for imaging and targeting cancers
Chen et al. A Cy5. 5-labeled phage-displayed peptide probe for near-infrared fluorescence imaging of tumor vasculature in living mice
Ebert et al. Cyanine dyes as contrast agents for near-infrared imaging in vivo: acute tolerance, pharmacokinetics, and fluorescence imaging
Patel et al. Two-color fluorescent (near-infrared and visible) triphasic perfluorocarbon nanoemulsions
Li et al. Near-infrared fluorescence imaging of CD13 receptor expression using a novel Cy5. 5-labeled dimeric NGR peptide
Xiao et al. Heptamethine cyanine based 64Cu-PET probe PC-1001 for cancer imaging: Synthesis and in vivo evaluation
Kanazaki et al. Development of human serum albumin conjugated with near-infrared dye for photoacoustic tumor imaging
Feng et al. Dual modal ultra-bright nanodots with aggregation-induced emission and gadolinium-chelation for vascular integrity and leakage detection
Goergen et al. In vivo fluorescence lifetime detection of an activatable probe in infarcted myocardium
Bakalova et al. Chemical nature and structure of organic coating of quantum dots is crucial for their application in imaging diagnostics
Temma et al. Preclinical evaluation of a novel cyanine dye for tumor imaging with in vivo photoacoustic imaging
Botz et al. Hydrophobic cyanine dye-doped micelles for optical in vivo imaging of plasma leakage and vascular disruption
Hwang et al. In vivo cellular-level real-time pharmacokinetic imaging of free-form and liposomal indocyanine green in liver