Volume 33

This issue launches our special series on proteostasis that highlights various facets of how the cell maintains proteome equilibrium, from protein quality control in translation to autophagy.

See NSMB team editorial

Yu et al. show the mechanism of inhibition of bacterial Cas activity by phage anti-CRISPR proteins, whereas Jasnauskaitė et al. show how the bacterial retron Eco2 defends against viruses by cutting RNAs and shutting down protein production to stop phage replication.

See Yu et al. and Jasnauskaitė et al.

Yan et al. show that the DNMT3A2–DNMT3L complex dynamically combines various signals to de novo methylate chromatin during early development to demarcate chromatin, akin to lampposts lighting up a street.

See Yan et al.