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Method of the Year 2025: EM-based connectomics
Our choice for the Method of the Year 2025 is EM-based connectomics, for the detailed insights into brain structure and function that the generated wiring diagrams enable.
Image: Amy Sterling, FlyWire and Princeton University -
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Methods development in Cryo-ET and in situ structural determination
The editors invite manuscripts that highlight methodological developments in instrument design, sample preparation, data acquisition, data analysis, interpretation and integration from different techniques.
Image: © enot-poloskun/Stock Photos/GetttyImagesOpen for submissions -
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Creature Column
Creature Columns introduce the many organisms used in research in labs around the world.
Image: Tatiana Sandoval-Guzmán -
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Spotlight on methods to study cancer
This Collection showcases several recent Reviews, Perspectives, Comments, research papers, and news articles discussing and reporting methods to study the complex biology of tumors.
Image: Science Photo Library / Getty Images. -
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A year of stem cell and developmental biology
In recent years, the field of stem cell and developmental biology has seen remarkable breakthroughs that have deepened our understanding of how organisms grow, age and regenerate, with major implications for medicine and biotechnology.
Image: Dr. Christopher Thomas, Marseille Developmental Biology Institute (IBDM), CNRS & Aix-Marseille Université -
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Focus on bond-selective imaging
This Focus issue highlights the history and future of vibrational imaging.
Image: Tao Chen, Marzia Savini & Meng Wang -
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The MICrONS Project
The MICrONS Project set out to create a massively dense reconstruction of the structural connections and functions of an entire millimeter volume of mouse visual cortex, along with new artificial intelligence-driven tools.
Image: Forrest Collman; Microns Consortium -
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Method of the Year 2024: spatial proteomics
Spatial proteomics is our pick for Method of the Year 2024, for the impact that these technologies have had on the understanding of the organization, structure and function of complex tissues, including in global tissue atlas projects.
Image: Elham Karimi and Simon Milette, from the Walsh and Quail Labs, Rosalind and Morris Goodman Cancer Institute -
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The Human Cell Atlas: towards a first draft atlas
Established in 2016, the Human Cell Atlas (HCA) consortium set out to create a comprehensive biological map of cells within the human body.
Image: Claire Agosti/SayoStudio; Concept: Ania Hupalowska -
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The Human Tumor Atlas Network (HTAN): exploring tumor evolution in time and space
Studying the evolution of cancer malignancy in space and time provides clues that are crucial for understanding how tumors develop, how they evade the immune system, and how they resist therapy and recur.
Image: Jessica Johnson -
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Nobel Prize in Chemistry 2024
The 2024 Nobel Prize in Chemistry has been awarded to David Baker “for computational protein design” and to Demis Hassabis and John M. Jumper “for protein structure prediction”.
Image: Springer Nature/The Nobel Foundation/Imagesource