ProTact, an SE(3)-invariant geometric GNN, enhances protein-protein contact prediction and docking by integrating physics-informed constraints. It surpasses existing methods in low MSA scenarios and enhances AlphaFold3’s confidence scores.

Modulating microbial intake helps to maintain the gut microbiome diversity as shown by mathematical modeling of intermittent migration to a community undergoing birth, death, and homogeneous competition in a biologically realistic regime.

The psychedelic substance psilocybin modifies the temporo-spatial aspects of global infraslow cortical activity across the serotonin receptor landscapes. These findings provide a link between macroscopic signatures of neuromodulatory activity, global brain events and receptor action, with relevance for understanding the mechanisms of psychedelic effects.

Simulated microgravity reveals species-specific effects on sperm navigation, fertilization, and early embryo development, highlighting compensatory mechanisms and chemical cues critical for reproduction in future space missions.

Machine learning and deep learning reveal that bivalent histone modifications in mouse embryonic stem cells is encoded evolutionarily conserved DNA sequences and motifs associated with transcription factors that regulate developmental genes

AutoFISH provides a cost-effective, open-source toolbox for automated smFISH, offering integrated hardware, software, and optimized protocols to streamline spatial gene-expression profiling in cell lines and cleared tissue samples.

Mechanistic modelling identifies conduit geometric constraints on torus-margo membrane function, resolving the surprising absence of this low-resistance, high-safety design in vessel-bearing plants.

This study combines perturbation experiments and simulations to examine anticipatory postural adjustments in an optimized predictive control framework, showing how preparatory COM shifts and muscle activity arise before predictable disturbances.

The ubiquitin ligase RNF183 regulates the ion transporter NKCC1 under hyperosmotic stress through ubiquitin-dependent mechanisms, providing new insights into osmoadaptive regulation of membrane transporters.

A gene-interaction analysis identifies gene pairs associated with alcohol use disorder severity in an American Indian cohort.

Dr. Victor Borda is a Research Associate at the University of Maryland, School of Medicine, and the Institute for Health Computing. In this Q&A, we discuss his recent publication in Communications Biology on admixture and genetic diversity across Peru, his work with the Peruvian Genome Project, and the relevance of developing genomic resources in Latin America.

This comment delves into the need for statistically rigorous population estimation in cryo-electron microscopy. Examples are given illustrating the failure of particle counting and the robustness of principled techniques.

This Q&A explores the interdisciplinary advances in the EU Pathfinder project Microbial Hydroponics (Mi-Hy) and its SPIKA installation - a functional prototype installed at the Milan Triennale 2025. In this prototype, microbial electrochemistry, engineered biomineralization, and metabolic programming converge. Researchers Ezgi Öğün Ramalhete, Işıl Yücel, and Jorge Barriuso discuss how microbial consortia can reshape the foundations of the built environment by introducing a platform for sustainable agriculture. This might enable a transition from resource-consuming architecture to circular, living infrastructure.

A recent cavefish study overturns the classic view of photolyases as light-dependent enzymes. Research shows CPD photolyase repairs oxidative DNA damage in darkness, revealing a dual function that explains its conservation in cave species

Delta glutamate receptors are no longer considered silent scaffolds. This Comment discusses how GluD2 can be activated by structural asymmetry and temperature, emphasizing its potential role in synaptic plasticity.

Artificial intelligence is rapidly transforming structural biology and accelerating access to protein structures, yet many Africa-based scientists still lack infrastructure, training opportunities, and sustained mentorship to fully benefit. Here, we describe BioStruct-Africa’s community-driven framework integrating AlphaFold, experimental structural biology, and computational drug design to train 1000 scientists over the next decade.