Seemingly random ex-cons are dying in seemingly random unexpected ways. Murphy investigates. Meanwhile, Harry, feeling guilty, wonders if he should stop helping Murphy solve crimes, since his help usually gets her into more trouble that his help is worth. He wonders if he should stop getting involved in her cases, despite the loss of income that it would cost him.
Meanwhile, Murphy's ex-Chicago-cop father Joe Murphy is visiting from his retirement home in Florida, and he has nothing but suspicion about Harry and his relationship with his daughter. I loved watching Murphy standing up to her Dad! You could tell that she loved him, but she also didn't want to put up with his nonsense! (and by nonsense, I mean a word that rhymes with SPIT.)
The title (Second City), aside from being Chicago's nickname, is also quite apropos, as the victims are all people who have been given a "second chance" at life, finding redemption after some life-threatening situation. Someone apparently is stealing those second chances to extend their own life! Talk about underhanded!
Guest characters include a celebrity detective who is great at gathering headlines, and his opportunistic biographer, both of which are considered quite suspect by Harry and Murphy.
At one point, Harry needs Murphy to slap him in order to enhance his detecting sensitivies. She refuses, so he kisses her, eliciting the slap that he needs. But, the very final line of the episode is Murphy telling him "It won't happen again." Which to me, kind of implies an upcoming romance. Of course it never happened, as this was the final episode of the series. But we can dream, right?