Glenn Close, who played the first live-action Cruella DeVil in La carica dei 101 - Questa volta la magia è vera (1996) and La carica dei 102 - Un nuovo colpo di coda (2000), serves as executive producer for this movie.
Costume designer Jenny Beavan, whom Gillespie hired after seeing her work on Mad Max: Fury Road (2015), created 277 costumes for the principal cast, including 47 for Cruella.
The film seen on TV while Cruella is in the hotel room is Alfred Hitchcock's I prigionieri dell'oceano (1944). The scene shows actress Tallulah Bankhead, on whom the animated appearance of Cruella DeVil was based.
A popular myth is that filming was delayed due to Emma Stone dislocating her shoulder at a Spice Girls concert in London, where she fell off her friend's shoulders in June 2019. Stone later explained that the night before the Spice Girls concert she was running in boots on a wood floor, slipped, and broke her shoulder in two places. She went to the concert with her arm in a sling, and didn't go in for an X-ray until the next day. Filming was delayed while Stone went to physical therapy.
Horace compares dog owners looking like their dogs in the same way that Pongo does in La carica dei cento e uno (1961).