Dennis Dugan, credited as "Director Película", is a real-life American filmmaker. He directed Santiago Segura in the comedy Jack e Jill (2011).
Antonio Resines, who played Toño in the movie, was the first choice to play Agustín in Padre no hay más que uno 3 (2022), but he was unavailable because Resines was hospitalized after complications with Covid19, being replaced by Carlos Iglesias. Santiago Segura dedicated to him the movie crediting him in the cast as "No sale pero le queremos", which translates as "He isn't but we love him". Segura and Resines worked together previously in La Niña dei tuoi sogni (1998), Muertos de risa (1999), Torrente 2: Misión en Marbella (2001), El oro de Moscú (2003), ¡A todo tren! Destino Asturias (2021), De Caperucita a loba (2023) and Vacanze a tempo pieno (2023).
Florentino Fernández plays a priest in the movie, as he did too in Padre no hay más que uno 2: La llegada de la suegra (2020). In Padre no hay más que uno 3 (2022) he played a different role as "Marido Vecina".
Reunites Santiago Segura with Neus Asensi after Torrente: El brazo tonto de la ley (1998). Both movies are directed by Segura.