Although it's never mentioned in the series, in the comics, Skaar is actually the biological son of Hulk. It remains unclear why this story element was never introduced in this show.
Several characters make reference to having seen Marvel Cinematic Universe films such as The Avengers (2012) and Guardiani della Galassia (2014), making the MCU a fictional part of this version of the Marvel Universe (Earth-12041).
This show features two cast members that had appeared in Buffy l'ammazzavampiri (1997), Seth Green and Eliza Dushku.
The voice of Red Hulk, Clancy Brown is also the voice of Mr. Krabs on SpongeBob SquarePants (1999) another red-skinned ex-military man. The voice of SpongeBob, Tom Kenny has a cameo in this show in the episode Mission Impossible Man (2014) as the eponymous Impossible Man.
This is the third collaboration between Eliza Dushku and Seth Green as they were in Buffy the vampire slayer together. Eliza Dushku and Seth Green were also in Angel but they didn't share any scenes together.