Ashburn's yearbook is Sandra Bullock's actual 1982 yearbook from Washington-Lee High School in Arlington, Virginia. The art department digitally manipulated Bullock's picture to include glasses and braces, neither of which she had in her original high school senior portrait. They also took out all the signatures within the book.
Husband and wife actors Ben Falcone and Melissa McCarthy have appeared in several movies together including: The Nines (2007), Le amiche della sposa (2011), Io sono tu (2013), Corpi da reato (2013), Tammy (2014), Spy (2015) and The Boss (2016).
The voice of the neighbor who's calling for her cat to come back from Ashburn's apartment is Melissa McCarthy (uncredited).
In the version shown in Lithuania, the classic "Balls" scene is dubbed to "brains." It worked fine until she says, "Little girl brains, if little girls had brains."
The movie was set for an April 5th release, but it was pushed back two months due to positive reception from the studio, who thought it had better playability as a summer release.