This is the second television series starring Gillian Anderson with a scene in the pilot episode in which a man spray-paints an X on a remote country road and that X later plays an important role in the plot; the first was X-Files (1993).
Rachael Taylor and Lance Gross have both played doctors in Grey's Anatomy (2005) but in different seasons.
This is the second show where Dermot Mulraney and Halston Sage acted together. The first was Prodigal Son