Ryan's (Matthew Perry) first line of the series is the same first line he says in the premiere of The Odd Couple (2015), in which he also starred.
The character Lauren once introduces herself as Lauren Bennett, a play on the name of the actress who plays her, Laura Benanti.
The logo design for the show's title (the uppercase word "GO" with the O tilted 45 degrees away from the G, and the uppercase word "ON" directly below "GO") is a reference to Robert Indiana's iconic Pop Art-era "LOVE" artwork. Indiana first designed this artwork in 1965 as a Christmas card for New York's Museum of Modern Art, Indiana has reconfigured the design in many formats (including prints, postage stamps, and sculptures) and languages (including Hebrew and Chinese).
Ryan once mistankely calls the character Lauren Laura, which is the name of the actress who plays her.
The name Ryan comes from the Gaelic-Irish word meaning King, which is Ryan's last name.