According to director John Hyams, the final fight between Scott Adkins and Jean-Claude Van Damme was meant to be much flashier and more acrobatic but had to be scaled back when Adkins tore a ligament in his knee prior to filming.
This film marks the reunion of Scott Adkins, Jean-Claude Van Damme and Dolph Lundgren after I mercenari 2 (2012).
Andrei Arlovski plays a UniSol named Magnus in this movie. In Universal Soldier: Regeneration (2009), he played a different UniSol called NGU.
Excluding the Matt Battaglia films Brothers in Arms and Unfinished Business Jean-Claude Van Damme is the only actor to play Luc Deveraux in the main temporal sequence of the Universal Soldier film series.