According to producer Brad Winderbaum, this show is the first MCU property to acknowledge the events of Daredevil (2015). In the official trailer, a brief scene from the Netflix show was also added, further confirming the continuity.
This is the first MCU series on Disney+ to release all episodes at once, similar to Netflix, instead of the traditional cable-style weekly release strategy.
Alaqua Cox is the first disabled actress to play a titular leading character in a Marvel Studios production. She was born deaf, just like the character in the original comics, and has a prosthetic leg.
The first series under the Marvel Spotlight banner, a series of standalone shows with "grounded, character-driven stories" and less impact on the larger MCU narrative.
Hawkeye (2021) directing duo Amber Templemore and Bertie Ellwood (Bert and Bertie) chose not to work on the series saying "We love the character of Echo, but... the Native American story of [Echo], in our opinion, should really be told by someone in that community."