This marks Mia Sara's return to acting since 2013. She had retired but told filmmaker Mike Flanagan she would return to acting for him after watching Midnight Mass (2021).
The Life of Chuck started filming in Alabama in 2023 during the SAG-AFTRA strike against Hollywood studios. It was allowed to film despite the strike because it was given a waiver under an interim agreement program that allowed independent productions with no direct ties to members of the Alliance of Motion Picture and Television Producers to shoot.
On-screen debut of Cody Flanagan, who plays 7-year-old Chuck in Act 1. He is director and screenwriter Mike Flanagan's son.
When Marty is in the traffic jam there is a Christine-look-alike red and white 1958 Plymouth Fury next to him.