This is the first series that Casey Kasem does not voice Shaggy. However, in this series, he does voice Shaggy's rich and on-the-run uncle Albert.
The character design of Dr. Phinius Phibes is very based on Bruce Timm who co-produced "Batman: the Animated Series" along with Eric Radomski (who developed this show)
This was the last television cartoon series project to have Joseph Barbera as an executive producer where he was involved in some episodes of the first season until his death on December 18, 2006. However, Barbera was replaced by Sam Register in the second season.
This was the last Scooby-Doo TV series to be aired on Kids' WB!.
The final Scooby-Doo TV series to premiered for Saturday Morning cartoons since Scooby-Doo, dove sei tu? (1969), and the final Scooby-Doo series to be premiered on a broadcast channel and later Scooby-Doo shows were aired on Cartoon Network.