For Michael Chiklis' performance as "Thing", a new set of prosthetics were developed. These prosthetics were easier for Chiklis to wear, as they provided better ventilation and could be easily removed, in comparison to the previous film's prosthetics which required six hours to apply, were uncomfortable and could not be easily removed.
Jessica Alba wore a blonde wig because her hair had suffered from all the bleaching in I Fantastici 4 (2005).
The studio hated Doctor Doom's make-up so he remains hidden under a cowl in most of his early scenes.
The forest scenes were shot in the same forest as was used in the first three "X-Men" movies.
The Silver Surfer was created by Doug Jones wearing a prosthetic suit developed by Spectral Motion, and a new VFX program from Weta Digital which augmented the Surfer's reflective surface.
Stan Lee: (at around 19 mins) as a guest who is refused entry to the Fantastic wedding. This is taken from an issue of the 1960s "Fantastic Four" comic, where at Reed Richards and Susan Storm's wedding, Stan Lee and series artist Jack Kirby are turned away from the wedding, in a blatant breaking of the fourth wall, which was very rare in the mainstream Marvel Comics universe.