Craig Ferguson's sidekick Geoff Peterson was created by MythBusters (2003) regular Grant Imahara after losing a wager to Ferguson that his Twitter followers couldn't get Imahara one hundred thousand Twitter followers of his own.
The opening theme was sung by Craig Ferguson.
CBS held auditions for the host job by letting their nominees host for one week, which Craig Ferguson obviously won. The others who auditioned were Michael Ian Black, Damien Fahey, and D.L. Hughley.
In the "Pick a Pic" opening, which says that it's time to play "Pick a Pic", there are twenty-four briefly flashed pictures. These pictures are on a loop which displays them three times throughout this opening.
Johnathan Magnum and Craig Ferguson, both Appeared in The Drew Carey Show.