Drake Bell and Josh Peck stated in 2019 that they would be interested in doing a more adult oriented reunion of the show.
Supporting characters later make guest appearances on other shows created by Dan Schneider. Craig and Eric appear in the iCarly (2007) episode iStart a Fan War (2010), and Helen appears in the Victorious (2010) episode Helen Back Again (2011).
The scene where Drake and Josh work at a sushi conveyor belt is inspired by Job Switching (1952), in which Lucy and Ethel are working at a chocolate conveyor belt.
The Premiere's marquee at the end of season four features "Now She's Carly," referring to actress Miranda Cosgrove transition from Megan to Carly in iCarly (2007).
The original pilot, which features a different actor playing Josh's father, has never been aired or released.