According to an interview, Jennifer Aniston stated that the reasons she worked on this film was both to work with her friend Ben Stiller and to dance the salsa.
While promoting the film on a talk show, Ben Stiller mentioned that the ferret bit him a couple of times during production, one time latching onto his chin.
At one point, Jennifer Aniston was shooting Friends (1994), Una settimana da Dio (2003), and "Along Came Polly" (2004) at the same time.
In a 2015 interview, Jennifer Aniston revealed that one week while filming she broke her toe and had to keep doing the rest of the film while being injured.