John Cleese plays a character called Donald Sinclair. This was actually the name of the real-life hotel proprietor on whom Cleese's iconic character, Basil Fawlty of Basil e Sybil (1975), was based.
A deleted scene further exaggerated the gambling habits of Sinclair and his associates; this scene featured them playing Monopoly with real money.
Vince Vieluf, who portrays Blaine Cody, did not appear on any of the film's posters or promotional material, even though he is one of the main characters. This was due to an agent who tried to secure star billing and failed. Vieluf has since fired the agent.
The script originally called for one tour guide in the Barbie museum, but Jerry Zucker liked the pair who ultimately made it into the film so much that he split the role.
Abdul Goznobi: as an extra in the background wearing a light green shirt, as Nick checks out of the hotel in Vegas.