Bob Saget and Dave Coulier became friends through the L.A. Comedy circuit. Coulier lived on Saget's couch in his early days as a comedian, similar to struggling comedian Joey Gladstone residing in the basement of Danny Tanner's house.
Mary-Kate Olsen is left-handed and Ashley Olsen is right-handed. That is why, throughout the show, Michelle uses both of her hands to write and eat.
The mother of the girl, Pam, who was Danny's wife, was killed by a drunk driver in a car accident, as revealed in one episode.
Bob Saget considered leaving the show after the first season due to his disapproval of the writing and story lines.
Mary-Kate Olsen and Ashley Olsen were chosen for the part of Michelle because they were the only twin babies that didn't cry at the audition.