The title and plot are a bit of a spoof on the oft borrowed theme of Dr. Jekyll and Mr. Hyde.
Jerry borrows a very Bugs Bunny signature move when he kisses Tom after being caught.
The junior chemistry kits popular at the time contained actual chemical ingredients and could be hazardous. Modern versions are much less toxic, but still lots of fun for budding science aficionados.
Not only do both characters break the fourth wall, they make sounds (but don't speak).
Tom uses state of the art film and projection equipment (for the time) to capture evidence of the mysterious food thief (Jerry).