Acquanetta, who plays the high priestess of the leopard cult, was an exotic-looking actress who appeared in several low-budget adventure movies in the 1940s and 1950s. She was born in Wyoming, with the pedestrian-sounding birth name of Mildred Davenport. She claimed that her great-grandfather was the illegitimate son of the King of England. She was also half Arapaho Indian.
This film's director, Kurt Neumann, had his greatest success with the 1958 sci-fi cult classic L'esperimento del dottor K. (1958). Unfortunately, he never got to enjoy its success---he died only a month after it was released.
The impassioned speeches Dr. Lazar (Edgar Barrier) delivers to the Leopard Tribe about protecting their cult and homeland feature gestures, facial expressions and vocal inflections clearly intended to remind 1946 audiences of Adolf Hitler.
This was the next-to-last of Johnny Sheffield's eight appearances as "Boy" opposite Johnny Weissmuller as Tarzan. In 1949, he made the first of his 12 movies as Bomba, essentially a low-budget, adolescent equivalent of Tarzan.
Following Tarzan e la donna leopardo (1946), Johnny Weissmuller would make Fiamme nella jungla (1946), opposite Buster Crabbe. "I took one look at that picture and went back to the jungle!" Weissmuller later said. Indeed, after "Swamp Fire" he starred in two more Tarzan pictures and then began a new franchise, playing "Jungle Jim" for virtually the rest of his career.