Curly Howard's deteriorating health due to having experienced a succession of small strokes is quite obvious, as is evident in this film by his halting speech and slowed reactions. He would only make three more Three Stooges films before finally succumbing to a massive stroke during filming of the third one, ending his career. He did make an uncredited cameo in a 1947 Stooges short with Shemp, but retired after that. He would go on to suffer two more massive strokes after retiring, the final one ending his life in 1952.
After Moe bites Curly's leg in the bedroom, Curly yells in his real voice, not his usual high-pitched voice.
Production #4063.