When the streaming application Peacock launched in July 2020, A.P. Bio was the first and only show renewed for the platform. Patton Oswalt and Glenn Howerton were publicly involved in the campaign to save the show after NBC cancelled the series.
Allisyn Snyder came up with many of the quirks and mannerisms for the character Heather, such as leaning to the side to peek out, and erratically looking around the room during long takes early on where she didn't have any lines. She was, purportedly, doing this to stay awake and entertain herself, but wasn't aware that show runners noticed this, asked her to do it for additional takes and even baked it into her character.
In July 2019, The Hollywood Reporter announced that AP Bio had been un-cancelled and season 3 will air NBCUniversal's upcoming streaming service.
All four seasons take place during the same school year. There are several lines throughout the series to suggest this. The most obvious is the character of Steph is pregnant in seasons 2, 3 and 4
Show creator (and SNL alumnus) Michael Patrick O'Brien attended high school in the real Ohio town in which A.P. Bio is set: St. John's Jesuit High School in Toledo, Ohio.