Priscilla Chan nació el 24 de febrero de 1985 en Massachusetts, Estados Unidos. Está casada con Mark Zuckerberg desde el 19 de mayo de 2012. Tienen dos niños.
(May 19, 2012) Married her boyfriend of 9 years Mark Zuckerberg in Zuckerberg's backyard in an event that also celebrated her graduation from medical school. They met at a fraternity party during their sophomore year at Harvard.