Blassreiter

im surprised this hasn't been reviewed already...it was one of the better animes I've seen recently...

its set in a futuristic Germany (although everyone speaks Japanese), where humans have the technology to get enhanced by nanomachines that make them stronger and less vulnerable, but also angrier and more dangerous. These enhanced humans are called demoniacs and are policed by XAT. The unofficial leader of the demoniacs is Xargin, and he is one tough dude...

the story mostly follows an XAT member named Amanda, and her adopted brother Malek, along with a few other XAT members and a few randoms as they chase, hunt and learn about the demoniacs and try to stop Xargin...

the animation is awesome, although some purists might not like the CG mixed with it, but i think half the battles could not have been done without the CG. The character development is interesting and the story never gets boring, with plenty of action and metaphors to human behaviour and strange religious undertones. Anyway, check it out, its worth it, if u have the time...